{"product_id":"abcam-ab211870","title":"Abcam, ab211870, Anti-TALLA-1 antibody [CL0262]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nMouse Monoclonal TALLA-1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TSPAN7 aa 100 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:CL0262,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human TSPAN7 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P41732,\u003cbr\u003e\nEpitope:Binds to an epitope located within the peptide sequence NDERSRAVDHVQRSL as determined by overlapping synthetic peptides.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTALLA-1 also known as human T-cell acute lymphoblastic leukemia antigen 1 is a cell surface glycoprotein with a molecular weight of around 43 kDa. This protein is mainly expressed in T-cell acute lymphoblastic leukemia cells but not in normal mature T-cells making it a significant marker in specific pathological contexts. TALLA-1 has been studied for its role in cell adhesion and signal transduction indicating its function in cell communication and interaction.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein plays an important role in malignant T-cell development and proliferation. Its activity influences T-cell receptor pathways which are critical in the immune response. TALLA-1 is not typically part of a larger protein complex but it interacts with other surface molecules to execute its functions particularly in aberrant T-cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nStudies have shown that TALLA-1 is integrated into the T-cell receptor signaling pathway and the leukemogenesis pathway. These pathways associate it with proteins such as CD3 and ZAP-70 which are essential for T-cell activation and progression of leukemogenesis. The interactions within these pathways highlight the significant role TALLA-1 plays in T-cell transformation and immune signaling.\u003cbr\u003e\nTALLA-1 is prominently linked to T-cell acute lymphoblastic leukemia (T-ALL) and has been identified in cases of severe combined immunodeficiency (SCID). The protein's aberrant expression correlates with the aggressive nature of T-ALL where it serves as a biomarker for diagnosis and potential therapeutic target. Its interaction with pathways and other proteins like NOTCH1 further emphasizes its involvement in aberrant T-cell proliferative disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854731497641,"sku":"ab211870","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab211870","provider":"Iright","version":"1.0","type":"link"}