{"product_id":"abcam-ab214333","title":"Abcam, ab214333, Anti-Flavivirus E-glycoprotein antibody [HF8-2\/B2-2\/E10]","description":"\u003cp\u003eSize: 1mL\u003cbr\u003e\nMouse Monoclonal POLG antibody. Suitable for sELISA, ICC\/IF, WB and reacts with West Nile virus, Dengue virus 1, Dengue virus 2, Dengue virus 3, Dengue virus 4, Japanese encephalitis virus, Zika virus samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Dengue virus 1 Brazil\/97-11\/1997 Genome polyprotein.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HF8-2\/B2-2\/E10,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Dengue virus 1, Dengue virus 2, Dengue virus 3, Dengue virus 4, Japanese encephalitis virus, West Nile virus, Zika virus,\u003cbr\u003e\nApplications:ICC\/IF, sELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Dengue virus 1 Brazil\/97-11\/1997 Genome polyprotein.P27909,\u003cbr\u003e\nSpecificity:This monoclonal antibody reacts with a conformational epitope present in DENV1, 2, 3, 4, ZIKV, JEV and WNV.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.1% Proclin 150Constituents: 89.9% RPMI 1640, 10% Fetal Bovine Serum (FBS), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFlavivirus E-glycoprotein also known as the envelope protein E plays a mechanical role during the viral entry into host cells. Proteins such as Dengue E protein and HF8 are alternate names for this target. This E-glycoprotein is responsible for the attachment of the virus to host cell receptors and facilitating membrane fusion. The protein has a mass of approximately 53 kDa and is expressed on the surface of flaviviruses like dengue virus. This E protein is present in the envelope layer of the virion interacting with the host cell during entry.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe Flavivirus E-glycoprotein functions in the viral infection process and is a part of the viral envelope complex. It is involved in the initial stages of the viral life cycle mediating the binding of the virus to host cellular receptors. This protein undergoes conformational changes upon acidic pH exposure in endosomes which promotes the fusion of the viral and host membranes. The E glycoprotein's role is critical in viral pathogenesis and immune response evasion.\u003cbr\u003e\nPathways\u003cbr\u003e\nFlavivirus E-glycoprotein is important in the viral entry pathway and the immune escape mechanisms of flaviviruses. It interacts with other envelope proteins such as prM to facilitate efficient virus assembly and maturation. The E glycoprotein's interaction with the host's receptors is the initial step in the viral entry pathway making proteins involved in endocytosis and cellular trafficking like DENV envelope protein relevant to its function.\u003cbr\u003e\nFlavivirus E-glycoprotein is linked to mosquito-borne diseases like dengue fever and Zika virus infection. The protein's role in mediating viral entry makes it a target for vaccine and therapeutic development. Dengue E protein and proteins related to the immune response such as 4G2 are often considered in studies investigating protective measures against these viral infections. The relationship of E protein with host cell membrane dynamics highlights its significance in pathophysiology and as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854731956393,"sku":"ab214333","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab214333","provider":"Iright","version":"1.0","type":"link"}