{"product_id":"abcam-ab215274","title":"Abcam, ab215274, Anti-ApoER2 antibody [EPR3326] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ApoER2 antibody. Carrier free. Suitable for IP, WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR3326,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab215274 is the carrier-free version of\u003cbr\u003e\nab108208\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nApoER2 also known as apolipoprotein E receptor 2 or LRP8 is a member of the LDL receptor family weighing about 130 kDa. It is expressed mainly in the brain but also in the heart and other tissues. This receptor interacts with extracellular binding partners such as lipoproteins and reelin to mediate signal transduction across cell membranes. ApoER2 plays an important role in brain development and synaptic plasticity through these interactions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nApoER2 contributes to neural processes like synaptic transmission and neuronal migration. It forms part of a protein complex with reelin a process essential for dendritic spine development and long-term potentiation. Its involvement in transporting cholesterol and other lipids is critical for maintaining neuronal function and integrity.\u003cbr\u003e\nPathways\u003cbr\u003e\nApoER2 participates in the reelin signaling pathway which is important for brain layer formation during development. It also interacts with other proteins like Disabled-1 (Dab1) to propagate signals initiated by reelin binding. This pathway also links ApoER2 to the regulation of synaptic strength and plasticity which are significant in learning and memory processes.\u003cbr\u003e\nApoER2 has connections to Alzheimer's disease and schizophrenia. Its interaction with amyloid-beta precursor protein (APP) in Alzheimer's disease impacts plaque formation and neuronal cell loss. In schizophrenia altered reelin-ApoER2 signaling can disrupt synaptic functions suggesting its involvement in the disorder's pathophysiology. Understanding these interactions may offer insights into potential therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860423266473,"sku":"ab215274","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab215274","provider":"Iright","version":"1.0","type":"link"}