{"product_id":"abcam-ab219867","title":"Abcam, ab219867, Sotrastaurin, pan-PKC inhibitor","description":"\u003cp\u003eSize: 5mg \/ 10mg \/ 25mg\u003cbr\u003e\nMW 438.5 Da, Purity \u0026gt;99%. Potent, selective pan-PKC inhibitor (K i  values of 0.95, 0.64, 2.1, 3.2, 1.8, and 0.22 nM for PKCα, βI, δ, ε, η, and θ respectively in a cell-free assay) .  Prevents the production of various cytokines by activated T cells, macrophages, and keratinocytes  in vitro  and has been shown to inhibit an acute allergic contact dermatitis response in rats when dosed orally at 30 mg. Displays potential immunosuppressive activity.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:425637-18-9,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:438.5 Da,\u003cbr\u003e\nMolecular formula:C25H22N6O2,\u003cbr\u003e\nPubChem:10296883,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:Sotrastaurin,\u003cbr\u003e\nBiological description:Potent, selective pan-PKC inhibitor (Ki values of 0.95, 0.64, 2.1, 3.2, 1.8, and 0.22 nM for PKCα, βI, δ, ε, η, and θ respectively in a cell-free assay). Prevents the production of various cytokines by activated T cells, macrophages, and keratinocytes in vitro and has been shown to inhibit an acute allergic contact dermatitis response in rats when dosed orally at 30 mg. Displays potential immunosuppressive activity.,\u003cbr\u003e\nCanonical smiles:CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65,\u003cbr\u003e\nInChi:InChI=1S\/C25H22N6O2\/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18\/h2-9,14,26H,10-13H2,1H3,(H,29,32,33),\u003cbr\u003e\nInChiKey:OAVGBZOFDPFGPJ-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847497797801,"sku":"ab219867","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab219867","provider":"Iright","version":"1.0","type":"link"}