{"product_id":"abcam-ab220238","title":"Abcam, ab220238, Anti-ARIP4 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal ARIP4 antibody. Suitable for ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RAD54L2 aa 1250-1400.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human RAD54L2 aa 1250-1400. The exact immunogen used to generate this antibody is proprietary information.Q9Y4B4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nARIP4 also known as androgen receptor-interacting protein 4 or RAD54-like homolog 1 functions as an ATP-dependent chromatin-remodeling enzyme. Its molecular mass is approximately 150 kDa. ARIP4 tightly associates with chromatin structures and resides in the nucleus. This protein expresses mainly in tissues like the prostate and testis suggesting a specialized role in these locations.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nARIP4 participates in the modulation of androgen receptor (AR) activity. It serves as an important part of the chromatin remodeling complex altering chromatin architecture to regulate transcription. This interaction significantly impacts gene expression linked to androgen response elements (AREs). ARIP4 helps unwind DNA allowing access to transcriptional machinery and influencing steroid hormone responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nARIP4 plays a role in androgen signaling and DNA repair pathways. It interacts with androgen receptors facilitating gene transcription in response to androgen hormones. Additionally ARIP4 associates with components like RAD54L involved in homologous recombination repair contributing to DNA integrity maintenance. These pathways emphasize its roles in managing cellular response to hormones and genetic stability.\u003cbr\u003e\nARIP4's function impacts prostate cancer and androgen insensitivity syndrome. In prostate cancer its ability to modulate AR activity influences tumor progression and resistance to therapy. Dysregulation of ARIP4 contributes to maladaptive gene expression driving cancerous growth. In androgen insensitivity syndrome impaired ARIP4 function leads to inadequate androgen receptor activation disrupting normal male sexual development. ARIP4's interaction with AR is relevant in the pathogenesis of these conditions highlighting its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854239617193,"sku":"ab220238","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab220238","provider":"Iright","version":"1.0","type":"link"}