{"product_id":"abcam-ab220961","title":"Abcam, ab220961, Anti-MyoGEF antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MyoGEF antibody. Suitable for ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PLEKHG6 aa 1-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PLEKHG6 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q3KR16\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMyoGEF also known as Myosin II interacting GEF mechanistically acts as a guanine nucleotide exchange factor that regulates the activation of RhoA by facilitating the exchange of GDP for GTP. MyoGEF weighing approximately 85 kDa is expressed in various tissues with notable presence in muscle and neuronal cells. It specifically localizes to the mitotic spindle and cleavage furrow during cell division indicating its role in cytokinesis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMyoGEF participates in controlling the cytoskeleton through its involvement in actin-related processes. These actions are important during cell migration and mitosis where it assists formation and contraction of the actomyosin ring. MyoGEF works in conjunction with other molecules like Myosin II as part of larger protein complexes to manage cellular shape and transport functionalities.\u003cbr\u003e\nPathways\u003cbr\u003e\nMyoGEF functions prominently within the RhoA signaling and cell division pathways. In the RhoA signaling pathway it interacts with Rho kinases and modulates activities involving cytoskeletal dynamics. Through the cell division pathway MyoGEF ensures correct cytokinesis and is linked to proteins such as Ect2 which is essential for proper cell cycle progression.\u003cbr\u003e\nThere is involvement of MyoGEF in cancer progression and neurological disorders. Its dysregulation can be tied to improper cell division contributing to tumorigenesis. Additionally MyoGEF's connection to cytoskeletal abnormalities links it to neurological disorders where interactions with proteins like ROCK1 can lead to disrupted neuronal signaling.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854095798441,"sku":"ab220961","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab220961","provider":"Iright","version":"1.0","type":"link"}