{"product_id":"abcam-ab221158","title":"Abcam, ab221158, Anti-AICL antibody [EPR22061]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal AICL antibody. Suitable for IHC-P, IP, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR22061,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAICL also known as activation-induced C-type lectin is a type II transmembrane protein expressed mostly on myeloid cells especially in bone marrow. It has a molecular mass of approximately 30 kDa. AICL belongs to the C-type lectin family and is often co-expressed with other members of this family on monocytes and dendritic cells. Scientists have noted that AICL appears in both the cytoplasm and on the cell surface contributing to its interaction capabilities.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAICL interacts with innate immune processes and contributes to immune cell activation. It forms a complex with immune receptors such as the NK cell receptor NKG2D modulating immune responses. AICL's ligand-binding properties facilitate engagement in pathogen recognition and response enhancing the communication between innate and adaptive immunity. These interactions underline AICL's function in monitoring cellular stress and transformation.\u003cbr\u003e\nPathways\u003cbr\u003e\nAICL participates significantly in the immune response through the NKG2D signaling pathway. This pathway is essential for natural killer (NK) cell-mediated cytotoxicity linking AICL closely with NK cell activation mechanisms. Additionally AICL is involved in the cytokine signaling pathway which interacts with proteins like IL-15 that are important for immune cell proliferation and function. These pathways highlight AICL's role in regulating immune surveillance and response.\u003cbr\u003e\nAICL has significant association with leukemia and rheumatoid arthritis. In leukemia AICL expression affects the immune cell environment influencing the progression of the disease and patient prognosis. In rheumatoid arthritis altered AICL expression connects with the inflammation process where it interacts with proteins such as MICA possibly aggravating autoimmune responses. These links highlight AICL's importance in both hematological and autoimmune disorders driving interest in its potential as a diagnostic or therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844272804009,"sku":"ab221158","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab221158","provider":"Iright","version":"1.0","type":"link"}