{"product_id":"abcam-ab221980","title":"Abcam, ab221980, Anti-HIPK2 antibody [EPR3819] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal HIPK2 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Mouse, Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR3819,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:The immunogen used for this product shares 69% homology and 6 consecutive amino acids with HIPK1. Cross-reactivity with this protein has not been confirmed experimentally.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab221980 is the carrier-free version of\u003cbr\u003e\nab108543\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nRat: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHIPK2 also known as Homeodomain-interacting protein kinase 2 is a serine\/threonine kinase with a molecular mass of approximately 118 kDa. This protein plays a mechanical role in modulating transcriptional regulation and apoptosis. It interacts with homeodomain transcription factors influencing the activity of various gene promoters. Within cells HIPK2 is expressed widely in several tissues including the heart brain and liver highlighting its diverse functional involvement across different biological systems.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe wide-ranging actions of HIPK2 make it essential for cell growth apoptosis and stress response. HIPK2 associates with various transcription factors and other-binding partners forming dynamic complexes that mediate its functions. By phosphorylating target proteins it regulates p53 and promotes p53-mediated apoptosis making it an important part of stress response networks. Additionally HIPK2 is implicated in the regulation of Wnt signaling pathways which are important for cell proliferation and differentiation processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nHIPK2 plays an integrative role in apoptotic and Wnt signaling pathways. It serves as a facilitator of the DNA damage response primarily through the modulation of p53 activity. It also contributes to the Wnt signaling pathway by phosphorylating beta-catenin and enhancing its degradation therefore regulating cellular proliferation. The interactions of HIPK2 with proteins like p53 and beta-catenin illustrate its significant involvement in controlling cell fate and maintaining cellular homeostasis.\u003cbr\u003e\nHIPK2 is linked to various cancers and neurodegenerative diseases due to its role in apoptosis and cell cycle regulation. Disruption in HIPK2 activity leads to impaired apoptosis and contributes to tumorigenesis particularly in cancers like breast and colorectal cancer. In neurodegenerative disorders such as Alzheimer's disease abnormal HIPK2 activity is associated with altered cellular signaling. The relationship with key proteins like p53 further explains how deviations in HIPK2 function can lead to disease states making it a valuable target for therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46856029372585,"sku":"ab221980","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab221980","provider":"Iright","version":"1.0","type":"link"}