{"product_id":"abcam-ab222224","title":"Abcam, ab222224, Anti-SNAP23 antibody [EPR8538] - Low endotoxin, Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal SNAP23 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8538,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab222224 is the carrier-free version of\u003cbr\u003e\nab131242\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nWhat does low endotoxin mean?\u003cbr\u003e\nOur low endotoxin, azide-free formats have low endotoxin level (1 EU\/mg, determined by the TAL assay) and are free from azide, to achieve consistent experimental results in functional assays.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSNAP23 also known as Synaptosomal-Associated Protein 23 is an important component in the mechanism of vesicular trafficking. It has a molecular mass of approximately 23 kDa and functions as a t-SNARE (target membrane SNAP receptor) protein. SNAP23 is expressed in various tissues with high expression levels in the brain pancreas liver and adipose tissue. This protein facilitates the fusion of vesicles with target membranes by forming SNARE complexes which are essential for the exocytosis and endocytosis processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSNAP23 plays a significant role in the regulation of membrane fusion events and intracellular transport. It forms part of the SNARE complex which includes v-SNAREs on vesicle membranes and other t-SNAREs on target membranes. This complex orchestrates the docking and fusion of vesicles enabling the release of neurotransmitters and other cargoes in neuronal and non-neuronal cells. By mediating these events SNAP23 is important for neurotransmission insulin-regulated glucose uptake and other cellular processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nSNAP23 functions in the exocytotic and endocytic pathways where it aids in the accurate secretion and recycling of cellular components. It interacts with proteins like Syntaxin and VAMP (vesicle-associated membrane protein) to achieve precise vesicle targeting and fusion. SNAP23 is also implicated in insulin-signaling pathways where it modulates GLUT4 translocation to the cell surface a process vital for maintaining glucose homeostasis. These interactions underline its involvement in both neural communication and metabolic regulation.\u003cbr\u003e\nSNAP23 has been associated with metabolic conditions such as type 2 diabetes and neurological disorders. The protein's function in insulin-regulated glucose transport suggests its relevance in diabetes where impaired glucose uptake occurs. In neurological contexts alterations in SNAP23 expression or function might contribute to disorders affecting synaptic transmission. Additionally its connection with proteins like GLUT4 and VAMP highlights SNAP23's role in disease contexts providing a linkage between vesicular transport and disease pathology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851786801321,"sku":"ab222224","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab222224","provider":"Iright","version":"1.0","type":"link"}