{"product_id":"abcam-ab223034","title":"Abcam, ab223034, Anti-DDIT4L\/REDD2 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal DDIT4L\/REDD2 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DDIT4L aa 1 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human DDIT4L aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96D03\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe DDIT4L\/REDD2 protein known alternatively as DDIT is a member of the DNA damage-inducible transcript family with a molecular mass of approximately 23 kDa. It is encoded by the DDIT4L gene and is expressed in multiple tissues with higher expression levels in muscle and fat tissues. This protein plays a role in cellular stress responses and has been associated with the regulation of cell growth and apoptosis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDDIT4L\/REDD2 influences response to cellular stress signals and acts as an inhibitor of the mTOR pathway—an essential regulator of cell metabolism growth and proliferation. It does not function as part of a large complex but interacts with other proteins to mediate its effects. By inhibiting mTOR activity DDIT4L can affect protein synthesis and autophagy reflecting its role in maintaining cellular homeostasis under stress conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nDDIT4L\/REDD2 is intricately involved in the mTOR signaling cascade and influences the PI3K\/AKT pathway two important pathways in cellular metabolism. Within these pathways it is related to proteins like TSC2 (Tuberous Sclerosis Complex 2) and AKT. DDIT4L exerts its effect by modulating signal transduction that impacts cell survival and stress responses making it an important player in the adaptation to environmental changes.\u003cbr\u003e\nAlterations in DDIT4L\/REDD2 expression are implicated in conditions such as cancer and metabolic syndromes. Aberrant regulation of this protein may lead to unchecked cell proliferation or metabolic imbalances involving proteins like mTOR and TSC2. These associations highlight the role of DDIT4L\/REDD2 in the maintenance of normal cellular functions and its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854214451369,"sku":"ab223034","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab223034","provider":"Iright","version":"1.0","type":"link"}