{"product_id":"abcam-ab223598","title":"Abcam, ab223598, GSK484, PAD4 inhibitor","description":"\u003cp\u003eSize: 1mg\u003cbr\u003e\nMW 510 Da, Purity \u0026gt;98%. Potent and reversible inhibitor of PAD4 (Protein Arginine Deiminase 4) (IC 50  = 50 nM). Selective for PAD4 over PAD1-3. GSK484 binds at a different site from the amidines, a conformation of the PAD4 active site where part of the site is re-ordered to form a β-hairpin. It blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1652591-81-5,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:510 Da,\u003cbr\u003e\nMolecular formula:C27H32ClN5O3,\u003cbr\u003e\nPubChem:86340151,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 50 mM,\u003cbr\u003e\nBiochemical name:((3S,4R)-3-Amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride,\u003cbr\u003e\nBiological description:Potent and reversible inhibitor of PAD4 (Protein Arginine Deiminase 4) (IC50 = 50 nM). Selective for PAD4 over PAD1-3. GSK484 binds at a different site from the amidines, a conformation of the PAD4 active site where part of the site is re-ordered to form a β-hairpin. It blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils.,\u003cbr\u003e\nCanonical smiles:CN1C2=C(C=C(C=C2OC)C(=O)N3CCC(C(C3)N)O)N=C1C4=CC5=CC=CC=C5N4CC6CC6.Cl,\u003cbr\u003e\nIsomeric smiles:CN1C2=C(C=C(C=C2OC)C(=O)N3CC[C@H]([C@H](C3)N)O)N=C1C4=CC5=CC=CC=C5N4CC6CC6.Cl,\u003cbr\u003e\nInChi:InChI=1S\/C27H31N5O3.ClH\/c1-30-25-20(11-18(13-24(25)35-2)27(34)31-10-9-23(33)19(28)15-31)29-26(30)22-12-17-5-3-4-6-21(17)32(22)14-16-7-8-16;\/h3-6,11-13,16,19,23,33H,7-10,14-15,28H2,1-2H3;1H\/t19-,23+;\/m0.\/s1,\u003cbr\u003e\nInChiKey:MULKOGJHUZTANI-ADMBKAPUSA-N,\u003cbr\u003e\nIUPAC Name:[(3S,4R)-3-amino-4-hydroxypiperidin-1-yl]-[2-[1-(cyclopropylmethyl)indol-2-yl]-7-methoxy-1-methylbenzimidazol-5-yl]methanone;hydrochloride\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B1035 GSK-484 hydrochloride. B1035-500 is the same size as the 500 µg size of ab223598.\u003cbr\u003e\nProtect from air and moisture.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847432917161,"sku":"ab223598","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab223598","provider":"Iright","version":"1.0","type":"link"}