{"product_id":"abcam-ab223601","title":"Abcam, ab223601, PFI-2, SETD7 histone lysine methyltransferase inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 499.5 Da, Purity \u0026gt;98%. A potent and selective SETD7 histone lysine methyltransferase inhibitor. K i  = 0.33 nM and IC 50  = 2 nM against SETD7. It displays \u0026gt; 1000-fold selectivity against DNMT1 and many other methyltransferases. No activity against 134 ion channel, GPCR, and enzyme targets (\u0026lt;35% inhibition at 10 μM). PFI-2 potently inhibits SETD7 in MCF7 cells.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1627676-59-8,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:499.5 Da,\u003cbr\u003e\nMolecular formula:C23H25F4N3O3S,\u003cbr\u003e\nPubChem:71300326,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:8-Fluoro-N-{(2r)-1-Oxo-1-(Pyrrolidin-1-Yl)-3-[3-(Trifluoromethyl)phenyl]propan-2-Yl}-1,2,3,4-Tetrahydroisoquinoline-6-Sulfonamide,\u003cbr\u003e\nBiological description:A potent and selective SETD7 histone lysine methyltransferase inhibitor. Ki = 0.33 nM and IC50 = 2 nM against SETD7. It displays \u0026gt; 1000-fold selectivity against DNMT1 and many other methyltransferases. No activity against 134 ion channel, GPCR, and enzyme targets (\u0026lt;35% inhibition at 10 μM). PFI-2 potently inhibits SETD7 in MCF7 cells.,\u003cbr\u003e\nCanonical smiles:C1CCN(C1)C(=O)C(CC2=CC(=CC=C2)C(F)(F)F)NS(=O)(=O)C3=CC4=C(CNCC4)C(=C3)F,\u003cbr\u003e\nIsomeric smiles:C1CCN(C1)C(=O)[C@@H](CC2=CC(=CC=C2)C(F)(F)F)NS(=O)(=O)C3=CC4=C(CNCC4)C(=C3)F,\u003cbr\u003e\nInChi:InChI=1S\/C23H25F4N3O3S\/c24-20-13-18(12-16-6-7-28-14-19(16)20)34(32,33)29-21(22(31)30-8-1-2-9-30)11-15-4-3-5-17(10-15)23(25,26)27\/h3-5,10,12-13,21,28-29H,1-2,6-9,11,14H2\/t21-\/m1\/s1,\u003cbr\u003e\nInChiKey:JCKGSPAAPQRPBW-OAQYLSRUSA-N,\u003cbr\u003e\nIUPAC Name:8-fluoro-N-[(2R)-1-oxo-1-pyrrolidin-1-yl-3-[3-(trifluoromethyl)phenyl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B1259 PFI-2. B1259-25 is the same size as the 25 mg size of ab223601.\u003cbr\u003e\nProtect from air.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847423119529,"sku":"ab223601","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab223601","provider":"Iright","version":"1.0","type":"link"}