{"product_id":"abcam-ab223883","title":"Abcam, ab223883, MK-8931, Beta-sectetase inhibitor","description":"\u003cp\u003eSize: 1mg \/ 5mg\u003cbr\u003e\nMW 409.4 Da, Purity \u0026gt;98%. MK-8931 is a selective, potent Beta-sectetase 1 inhibitor (IC 50  = 2.2 nM).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1286770-55-5,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:409.4 Da,\u003cbr\u003e\nMolecular formula:C17H17F2N5O3S,\u003cbr\u003e\nPubChem:51352361,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 75 mM,\u003cbr\u003e\nBiochemical name:Verubecestat,\u003cbr\u003e\nBiological description:MK-8931 is a selective, potent Beta-sectetase 1 inhibitor (IC50 = 2.2 nM).,\u003cbr\u003e\nCanonical smiles:CC1(CS(=O)(=O)N(C(=N1)N)C)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)F)F,\u003cbr\u003e\nIsomeric smiles:C[C@]1(CS(=O)(=O)N(C(=N1)N)C)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)F)F,\u003cbr\u003e\nInChi:InChI=1S\/C17H17F2N5O3S\/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14\/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25)\/t17-\/m0\/s1,\u003cbr\u003e\nInChiKey:YHYKUSGACIYRML-KRWDZBQOSA-N,\u003cbr\u003e\nIUPAC Name:N-[3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B1315 MK-8931. B1315-5 is the same size as the 5 mg size of ab223883.\u003cbr\u003e\nProtect from air and light.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nBACE1 and BACE2 also known as beta-secretase 1 and 2 are enzymes involved in the cleavage of amyloid precursor protein (APP). BACE1 with a mass of around 75 kDa is expressed mainly in neuronal tissues while BACE2 is found in various tissues including the brain and pancreas. These enzymes catalyze the initial step in the production of beta-amyloid peptides by cleaving APP at the beta-site. This enzymatic activity suggests critical roles in cellular processes especially in neural function and integrity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nBACE1 and BACE2 serve as key players in neurodegenerative pathways. They are known to form part of the gamma-secretase complex participating in the proteolytic processing of APP leading to the formation of amyloid-beta peptides. These peptides have significant implications in cell signaling and neuronal functions contributing to synaptic plasticity and overall brain health. BACE2 also has roles in pigment cell biology indicating its additional functions beyond the nervous system.\u003cbr\u003e\nPathways\u003cbr\u003e\nBACE1 and BACE2 are integral to the amyloidogenic pathway a central route in the pathogenesis of Alzheimer's disease. They are related to proteins such as APP and presenilin which influence the generation of amyloid-beta peptides. Another important pathway involving BACE1 is the Notch signaling pathway where its activity can influence cellular differentiation processes.\u003cbr\u003e\nBACE1 and BACE2 are closely linked to Alzheimer's disease and possible involvement in type 2 diabetes. Alzheimer's disease is characterized by the accumulation of amyloid-beta plaques which are a direct result of BACE1 activity. Proteins like APP and tau are connected to the pathophysiology seen in such neurodegenerative disorders. Additionally alterations in BACE2 are associated with metabolic processes that could influence glucose homeostasis implicating it in metabolic disorders like diabetes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847453135017,"sku":"ab223883","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab223883","provider":"Iright","version":"1.0","type":"link"}