{"product_id":"abcam-ab224046","title":"Abcam, ab224046, Anti-alpha-cardiac myosin heavy chain antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MYH6 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MYH6 aa 1000-1200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MYH6 aa 1000-1200. The exact immunogen used to generate this antibody is proprietary information.P13533\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAlpha-cardiac myosin heavy chain also known as alpha myosin or alpha MHC plays an essential role in muscle contraction within the heart. This motor protein has a molecular mass of approximately 223 kDa. It expresses predominantly in cardiac muscle tissue where it functions as a major component of the thick filaments in cardiac muscle cells. The high expression of this protein in the heart ensures effective force generation during systolic contraction.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAlpha cardiac myosin heavy chain contributes to the cyclical interaction with actin filaments which results in muscle contraction. It forms part of the myosin molecule complex together with its two light chains. The ATPase activity of alpha MHC enables it to convert chemical energy from ATP hydrolysis into mechanical work driving the sliding of actin filaments. This process is important for the maintenance of cardiac muscle contractility and heart function.\u003cbr\u003e\nPathways\u003cbr\u003e\nAlpha cardiac myosin heavy chain functions as a central element in the cardiac muscle contraction pathway. This pathway is essential for the effective pumping of blood by the heart. In this pathway alpha MHC interacts with actin to facilitate cross-bridge cycling which drives muscle contraction. Additionally it relates closely to other myosin heavy chains such as beta-myosin heavy chain which expresses depending on developmental stage or physiological condition ensuring adaptability of cardiac muscle performance.\u003cbr\u003e\nAlpha cardiac myosin heavy chain has strong links to hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Mutations in the alpha MHC gene can lead to impaired contractile functions resulting in these hereditary heart conditions. In HCM alpha MHC mutations often contribute to thickening of the heart muscle while in DCM mutations may lead to weakened contractions and enlargement of the heart chambers. This protein also interacts with other sarcomeric proteins like cardiac troponin T which can similarly influence cardiomyopathy development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854248136873,"sku":"ab224046","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab224046","provider":"Iright","version":"1.0","type":"link"}