{"product_id":"abcam-ab224059","title":"Abcam, ab224059, Anti-TRIM22 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TRIM22 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRIM22 aa 100-300.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human TRIM22 aa 100-300. The exact immunogen used to generate this antibody is proprietary information.Q8IYM9\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRIM22 also known as Staf50 is a protein encoded by the TRIM22 gene. It weighs approximately 56 kDa. TRIM22 is expressed in different tissues throughout the body including the spleen thymus and liver. This protein belongs to the tripartite motif (TRIM) family which is characterized by a distinct structure comprising a RING finger B-box domains and a coiled-coil region. The presence of a RING finger domain suggests that TRIM22 might have E3 ubiquitin ligase activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTRIM22 plays a significant role in innate immunity influencing the antiviral response. As an E3 ubiquitin ligase it facilitates the ubiquitination and degradation of host proteins that are involved in viral replication processes. TRIM22 does not generally function in a protein complex but it interacts with other proteins in a cellular context. This interaction enhances the cellular response against viral infections by disrupting viral components and inhibiting viral replication.\u003cbr\u003e\nPathways\u003cbr\u003e\nTRIM22 is involved in the IFN (interferon) signaling pathway which is essential for the immune response against pathogens. In this pathway TRIM22 interacts with proteins like IFNAR1 and STAT1 acting as a mediator of antiviral activities. It also participates in the ubiquitin-proteasome system aiding in the regulation of protein turnover within the cell. These pathways demonstrate the broad scope of TRIM22 in maintaining cellular homeostasis and responding to external immune challenges.\u003cbr\u003e\nTRIM22 has been linked to conditions such as systemic lupus erythematosus (SLE) and certain cancers. In SLE TRIM22 expression is often dysregulated contributing to an altered immune response. The protein also connects with STAT proteins which can be influential in autoimmune disease pathways. Moreover aberrant expression of TRIM22 has been observed in some cancer types suggesting a role in tumor biology and potentially offering a target for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854138757289,"sku":"ab224059","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab224059","provider":"Iright","version":"1.0","type":"link"}