{"product_id":"abcam-ab224081","title":"Abcam, ab224081, Anti-PTPIP51 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal PTPIP51 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RMDN3 aa 150-350.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human RMDN3 aa 150-350. The exact immunogen used to generate this antibody is proprietary information.Q96TC7\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPTPIP51 also known as Protein Tyrosine Phosphatase-Interacting Protein 51 functions at a mechanical level by interacting with protein tyrosine phosphatases and kinases which are key regulators of signal transduction. PTPIP51 has a molecular mass of approximately 51 kDa. The protein is expressed in various tissues including the brain testis and skeletal muscle. Its interactions suggest a role in maintaining cellular function and signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe PTPIP51 protein plays a role in cellular processes such as apoptosis and cellular differentiation. It is believed to associate with other proteins to form complexes which influence mitochondrial function and cellular energy metabolism. Through these interactions PTPIP51 aids in maintaining cellular homeostasis and regulating cell survival mechanisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nPTPIP51 participates in the regulation of the MAPK\/ERK pathway and the insulin signaling pathway. It interacts with proteins such as RAF1 and GRB2 to convey signals from the cell surface to the DNA in the cell nucleus affecting cell division and proliferation. These pathways highlight the protein’s importance in controlling cellular growth and reaction to external stimuli.\u003cbr\u003e\nPTPIP51 has connections to neurodegenerative disorders like Alzheimer's disease and metabolic conditions such as obesity. In Alzheimer’s alterations in PTPIP51 are linked with the dysregulation of mitochondrial function and it interacts with proteins such as Tau involved in neurofibrillary tangles. In obesity PTPIP51 is connected to insulin resistance engaging with protein partners like IRS1 to influence glucose uptake and metabolism.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854083149993,"sku":"ab224081","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab224081","provider":"Iright","version":"1.0","type":"link"}