{"product_id":"abcam-ab224093","title":"Abcam, ab224093, Anti-DHHC-5 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal DHHC-5 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZDHHC5 aa 450-650.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human ZDHHC5 aa 450-650. The exact immunogen used to generate this antibody is proprietary information.Q9C0B5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDHHC-5 also known as zDHHC5 or DHHC5 is a palmitoyltransferase enzyme located primarily in the plasma membrane of cells. It plays an important mechanical role by catalyzing the addition of palmitate to proteins through thioester linkage which is important for regulating protein localization stability and function. DHHC-5 has a molecular weight of approximately 48 kDa. It expresses widely in various tissues with prominent expression in the brain heart and lungs indicating its significance in multiple physiological systems.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDHHC-5 contributes to the modulation of signal transduction and cellular communication. This protein functions as part of a complex with its substrate proteins where it transfers lipid groups to them influencing their interaction with other molecules and membranes. By doing so DHHC-5 affects processes like synaptic plasticity cell adhesion and intracellular trafficking. Its role in these mechanisms suggests it is a versatile player in cellular network dynamics.\u003cbr\u003e\nPathways\u003cbr\u003e\nDHHC-5 is integral to the palmitoylation pathway which regulates protein trafficking and signaling. Within this framework it influences critical biological pathways such as the Wnt signaling pathway impacting cell fate determination. Additionally DHHC-5 interacts with other palmitoyltransferases and proteins such as G-proteins contributing to their localization and function by palmitoylating them and therefore playing a role in various signaling networks.\u003cbr\u003e\nDHHC-5 has been associated with neurological disorders such as schizophrenia and neurodegenerative diseases like Alzheimer's disease. Its altered function and expression can disrupt normal protein localization and signaling leading to pathophysiological states. In Alzheimer's disease DHHC-5 may affect proteins involved in amyloid precursor protein processing influencing the accumulation of beta-amyloid plaques. Understanding the connections between DHHC-5 and these disorders aids in comprehending its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854196461737,"sku":"ab224093","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab224093","provider":"Iright","version":"1.0","type":"link"}