{"product_id":"abcam-ab224444","title":"Abcam, ab224444, Anti-WDR79 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal WDR79 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human WRAP53 aa 100-250.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human WRAP53 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q9BUR4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nWDR79 also known as WRAP53 is a protein that assists in the assembly and maintenance of telomerase a ribonucleoprotein complex. It has a mass of approximately 80 kDa. The protein is mainly expressed in the nucleus of cells where it also interacts with components of Cajal bodies. Through these interactions WDR79 aids in the localization and stability of telomerase RNA (TERC) which is critical for telomerase activity. Additionally WDR79 interacts with p53 and acts as a cofactor for some spliceosomal small nuclear ribonucleoproteins (snRNPs).\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nWDR79 has a significant role in RNA processing and telomere maintenance. It is part of various ribonucleoprotein complexes where it serves as a scaffold facilitating RNA-protein interactions. WDR79 plays an essential role in the biogenesis of small Cajal body-specific RNAs (scaRNAs) which modify small nuclear RNAs (snRNAs). These modifications are necessary for proper splicing and maturation of pre-mRNA. Besides WDR79 is involved in the non-homologous end-joining (NHEJ) repair of double-strand breaks in DNA a critical cellular response to DNA damage.\u003cbr\u003e\nPathways\u003cbr\u003e\nWDR79 is centrally involved in telomere maintenance and RNA splicing pathways. In telomere maintenance it operates closely with the TERT and TERC components of the telomerase complex ensuring proper telomere elongation and genomic stability. In RNA splicing WDR79 interacts with proteins such as coilin which is integral to the organization and function of Cajal bodies where snRNP biogenesis occurs. The role of WDR79 in these pathways highlights its importance in regulating fundamental cellular processes.\u003cbr\u003e\nAlterations in WDR79 function are linked to cancer and dyskeratosis congenita. Mutations and deregulation of this protein disturb telomere maintenance and cause genomic instability conditions that often lead to cancer development. WDR79 has connections to proteins such as TERT in these pathways which when dysregulated promote oncogenesis. In dyskeratosis congenita impaired telomerase function due to defective WDR79 interactions leads to stem cell failure and tissue degeneration underlining the protein’s importance in tissue maintenance and cellular longevity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854173261993,"sku":"ab224444","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab224444","provider":"Iright","version":"1.0","type":"link"}