{"product_id":"abcam-ab224546","title":"Abcam, ab224546, Anti-SEC23IP antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal SEC23IP antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SEC23IP aa 850-950.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human SEC23IP aa 850-950. The exact immunogen used to generate this antibody is proprietary information.Q9Y6Y8\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSEC23IP also known as SEC23-interacting protein or p125 serves an important role in the assembly and functioning of the COPII complex. It weighs approximately 115 kDa and participates in transporting proteins from the endoplasmic reticulum to the Golgi apparatus. SEC23IP binds to SEC23 a component of the COPII coat and modulates the assembly process for vesicle formation. Expression of SEC23IP occurs in many tissues with significant levels observed in the liver and pancreas.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSEC23IP assists in mediating the selection and transport of cargo molecules by stabilizing the SEC23\/24 subcomplex within the larger COPII complex. SEC23IP therefore helps facilitate the budding of transport vesicles from the endoplasmic reticulum. By acting within this protein complex SEC23IP enhances the fidelity and specificity of cargo selection and compartmentalization essential for functional protein sorting.\u003cbr\u003e\nPathways\u003cbr\u003e\nSEC23IP acts as an indispensable component of the secretory pathway which ensures the proper trafficking of proteins through the cell. It interacts largely within the context of the COPII vesicle-mediated transport pathway and is influenced by proteins such as SAR1 and SEC24. These transport routes are necessary for maintaining cellular homeostasis and enabling cell surface membrane depiction.\u003cbr\u003e\nAlterations in SEC23IP expression or function have connections to conditions involving improper protein trafficking. One known association is with craniofacial abnormalities linked to disruptions in cellular transport processes. Mutations in related COPII proteins like SEC23 also highlight the consequences on skeletal development and metabolism which can manifest in conditions such as cranio-lenticulo-sutural dysplasia (CLSD). Understanding the exact role of SEC23IP contributes to insights into these developmental disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854198984873,"sku":"ab224546","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab224546","provider":"Iright","version":"1.0","type":"link"}