{"product_id":"abcam-ab224758","title":"Abcam, ab224758, Anti-Gemin 8 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Gemin 8 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GEMIN8 aa 1-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human GEMIN8 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q9NWZ8\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGemin 8 also known as Gemin8 is a small protein with a molecular weight of approximately 25 kDa. The protein is mainly expressed in the cell nucleus where it forms a part of the survival of motor neurons (SMN) complex. The SMN complex plays an important role in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs) which are essential components in RNA splicing. High levels of Gemin 8 expression can be detected in human tissues with high RNA splicing activity like the brain and spinal cord.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGemin 8 serves as a stabilizing element within the SMN complex. This complex is critical for biogenesis of snRNPs which are necessary for pre-mRNA splicing. In the absence or malfunction of Gemin 8 the SMN complex loses its structural stability leading to impaired snRNP assembly. In addition to its role in RNA processing Gemin 8 influences the transport of various RNAs and is vital for cellular RNA metabolism.\u003cbr\u003e\nPathways\u003cbr\u003e\nGemin 8 is an integral part of the RNA splicing pathway specifically engaging with the process of snRNP biogenesis and assembly. As part of the SMN complex Gemin 8 interacts with SMN1 protein which is important for efficient splicing of pre-mRNA. It also interacts with other Gemin proteins such as Gemin 2 and Gemin 6 which together ensure the proper assembly and recycling of snRNPs facilitating the accurate processing of RNA transcripts.\u003cbr\u003e\nAbnormalities in Gemin 8 activity are often linked to spinal muscular atrophy (SMA) a genetic disorder that affects motor neurons and leads to muscle wasting. Mutation or reduced expression of SMN1 a protein closely tied to Gemin 8 within the SMN complex contributes significantly to the pathology of SMA. Furthermore disruptions in Gemin 8 function may play a role in neurodegenerative disorders as efficient RNA splicing is important for maintaining neuron health. Researchers study Gemin 8 to develop therapeutic interventions aimed at restoring SMN complex functionality in SMA and related conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854221267113,"sku":"ab224758","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab224758","provider":"Iright","version":"1.0","type":"link"}