{"product_id":"abcam-ab224865","title":"Abcam, ab224865, Recombinant Putative Serine Protease Inhibitor protein (Tagged)","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Putative Serine Protease Inhibitor protein (Tagged) is a Fragment protein, in the 1 to 371 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nStorage buffer:pH: 7.2 - 7.4Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Putative Serine Protease Inhibitor also known as PSPI mechanically acts to inhibit serine proteases enzymes that break peptide bonds in proteins. Though the full mass of PSPI is still under research its inhibitory function is well-studied. PSPI expression primarily occurs in tissues with high proteolytic activity such as the pancreas and liver. These locations represent sites where enzyme regulation is critical for maintaining normal physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe Putative Serine Protease Inhibitor plays a role in regulating protease activity important for controlling protein digestion blood coagulation and immune response processes. It acts as part of a protease-protease inhibitor complex providing balance in physiological environments to prevent excessive protease action which can lead to tissue damage or disease. By modulating protease actions PSPI helps maintain equilibrium in cellular environments.\u003cbr\u003e\nPathways\u003cbr\u003e\nPSPI is an important component in both the coagulation cascade and complement system. These pathways are essential for wound healing and immune defense respectively. PSPI interacts with other proteins like thrombin an important serine protease in coagulation and complement factor C1 a component of the immune system. Through these interactions PSPI contributes to the regulation of these critical biological processes ensuring they proceed in a controlled manner.\u003cbr\u003e\nThe Putative Serine Protease Inhibitor relates to conditions such as pancreatitis and certain clotting disorders. Pancreatitis involves inflammation of the pancreas where imbalance in protease activity can accelerate tissue damage. PSPI by inhibiting serine proteases may influence disease progression or severity. In clotting disorders where regulation of coagulant activity is impaired PSPI's interaction with proteins like plasminogen can alter the disease state either exacerbating or mitigating symptoms. Understanding PSPI's role in these conditions can provide insights into potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843954331817,"sku":"ab224865","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab224865","provider":"Iright","version":"1.0","type":"link"}