{"product_id":"abcam-ab225937","title":"Abcam, ab225937, Anti-Arginine kinase antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal Arginine kinase antibody. Suitable for WB and reacts with Recombinant full length protein - Giant tiger prawn samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Giant tiger prawn AK.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Giant tiger prawn,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Giant tiger prawn AK.C7E3T4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nArginine kinase also known as AK is a phosphotransferase enzyme with a molecular mass around 40 kDa. It plays an important role in cellular energy homeostasis catalyzing the reversible transfer of a phosphate group from adenosine triphosphate (ATP) to arginine forming phosphoarginine and adenosine diphosphate (ADP). This enzyme is mainly expressed in invertebrates including species like mollusks arthropods and some protozoa. Arginine kinase is not typically found in the same form in vertebrates; instead creatine kinase performs a similar function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nArginine kinase functions in a manner that ensures energy storage and transfer in cells with rapid energy demands. It operates through temporal and spatial buffering of ATP levels during high-energy usage. This makes it particularly important in facilitating activity bursts in muscle- and nerve-tissues. Arginine kinase is not commonly part of large protein complexes; it acts as a monomeric enzyme performing its role independently within the cells where it is expressed.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis enzyme operates critically within cellular energy metabolism pathways. It connects directly with the phosphagen system an important energy reservoir for immediate cellular energy supply. Through this system arginine kinase relates closely to ATP and ADP molecules participating in the rapid regeneration of ATP from ADP. Though it is not as directly linked to glycolysis or oxidative phosphorylation as some other proteins arginine kinase supports these pathways by maintaining ATP levels constant during periods of variable energy demand.\u003cbr\u003e\nArginine kinase has an interesting relationship with parasitic diseases like Chagas disease caused by Trypanosoma cruzi. Some studies indicate that inhibitors targeting arginine kinase activity could provide therapeutic effects against the parasite as this enzyme appears essential for parasite survival. While it may not directly cause specific human diseases due to its absence in vertebrate physiology understanding its function and differences from human creatine kinase provides insights that are valuable for comparative enzymology and targeted drug design against invertebrate pests and parasites.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850114224297,"sku":"ab225937","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab225937","provider":"Iright","version":"1.0","type":"link"}