{"product_id":"abcam-ab22721","title":"Abcam, ab22721, Anti-Cytochrome P450 2B1 + 2B2 antibody [b\/e4 (9.20)]","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Monoclonal Cytochrome P450 2B1 antibody. Carrier free. Suitable for ELISA, WB, IP and reacts with Rat, Mouse samples. Cited in 1 publication. Immunogen corresponding to Full Length Protein corresponding to Rat Cyp2b1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:b\/e4 (9.20),\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Rat, Mouse,\u003cbr\u003e\nApplications:WB, ELISA, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Full Length Protein corresponding to Rat Cyp2b1. The exact immunogen used to generate this antibody is proprietary information.P00176,\u003cbr\u003e\nSpecificity:Clone b\/e4 does not react with CYP 1A1, 1A2, 2C6, 2C7, 2C11, 4A2, 4A3.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A\/G, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCytochrome P450 2B1 and 2B2 are enzymes that belong to the cytochrome P450 superfamily often referred to as CYP2B1 and CYP2B2 respectively. They are important in drug metabolism and chemical biotransformation. These enzymes have a role in oxidizing organic substances which helps in processing drugs in the liver. Each has a molecular mass of around 54 kDa and shows expression in tissues primarily in the liver and to some extent in the lungs.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCytochrome P450 enzymes including 2B1 and 2B2 function to metabolize endogenous and exogenous compounds through monooxygenase activity. 2B1 and 2B2 do not operate in solitude but are involved with the cytochrome P450 complex which includes NADPH-cytochrome P450 reductase. This complex plays an integral role in enabling the metabolism of a wide variety of substrates such as steroids fatty acids and xenobiotics.\u003cbr\u003e\nPathways\u003cbr\u003e\nCytochrome P450 2B1 and 2B2 take part in the metabolic pathway of xenobiotics and various drugs. These pathways include hydroxylation processes necessary for drug detoxification and clearance. In this context CYP2B1 and CYP2B2 interact closely with other proteins like CYP3A4 which also plays a part in drug metabolism within the liver to ensure coordinated metabolic conversion of foreign chemicals.\u003cbr\u003e\nCYP2B1 and CYP2B2 have significance in conditions such as liver disease and certain types of drug-induced toxicity. The enzymes' altered activity can lead to improper drug clearance and toxic buildup contributing to liver disorders. They also have associations with specific proteins like GST (glutathione S-transferases) that aid in detoxification and changes in these interactions may exacerbate susceptibility to drug-related liver damage.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855370670249,"sku":"ab22721","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab22721","provider":"Iright","version":"1.0","type":"link"}