{"product_id":"abcam-ab228887","title":"Abcam, ab228887, Anti-MED18 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MED18 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MED18.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MED18. The exact immunogen used to generate this antibody is proprietary information.Q9BUE0\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMED18 also known as Mediator Complex Subunit 18 is a component of the mediator complex. This protein possesses a mass of approximately 26 kDa. MED18 is expressed in various tissues playing a role in transcription regulation. It serves as a bridge linking transcription factors with RNA polymerase II aiding in the control of gene expression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMED18 operates as part of the larger mediator complex which is essential in conveying signals from gene-specific regulatory proteins to the transcriptional machinery. The mediator complex a multiprotein structure acts as a platform for the assembly of transcription factors and cofactors. Through its role in this complex MED18 directly influences RNA synthesis and gene transcription processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nMED18 is involved in critical biological pathways like the transcription initiation pathway and RNA polymerase II transcription machinery. The mediator complex where MED18 functions interacts closely with the pre-initiation complex. Proteins like MED1 and MED20 may have interactions with MED18 within these pathways contributing to its essential role in transcription regulation.\u003cbr\u003e\nMED18 has associations with certain cancers and neurological disorders due to its role in transcription misregulation. Aberrant expression or mutations in MED18 can impact cell growth and differentiation leading to tumor development. Additionally disturbances in MED18 function can link to MED1 as both are parts of the mediator complex contributing to disruptions in normal transcription regulation that could drive disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854196297897,"sku":"ab228887","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab228887","provider":"Iright","version":"1.0","type":"link"}