{"product_id":"abcam-ab228999","title":"Abcam, ab228999, Anti-DDX23 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal DDX23 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DDX23.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human DDX23. The exact immunogen used to generate this antibody is proprietary information.Q9BUQ8\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe DDX23 protein also known as DEAD-box helicase 23 is a member of the DEAD-box protein family. This family is characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and is involved in a wide range of cellular processes. DDX23 plays a mechanical role in unwinding RNA which is essential for RNA processing. The protein has a molecular mass of approximately 82 kDa. DDX23 is expressed ubiquitously across various tissues with significant expression in the nucleus where it contributes to RNA dynamics.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDEAD-box helicase 23 participates in the spliceosome complex important for pre-mRNA splicing a process that removes introns and joins exons to form mature messenger RNA. DDX23 acts during spliceosome assembly and the catalytic activation phase. Through its helicase activity it facilitates structural transitions within the spliceosome ensuring accurate splicing of pre-mRNA molecules. This function is essential for accurate gene expression and cellular function.\u003cbr\u003e\nPathways\u003cbr\u003e\nDDX23 is involved in the spliceosomal pathway and related RNA processing pathways. Its role in pre-mRNA splicing links DDX23 to the regulation of gene expression impacting numerous downstream pathways. Within these pathways DDX23 interacts closely with other spliceosome-associated proteins like PRPF8 and SNRNP200. These interactions ensure the efficiency and regulation of the splicing process critical to cellular and physiological functions.\u003cbr\u003e\nAlterations in the DDX23 function have been associated with conditions such as cancers and neurodegenerative diseases. Misregulation of DDX23 activity can lead to aberrant splicing events contributing to oncogenesis. Additionally DDX23 abnormalities correlate with neurodegenerative conditions where correct RNA processing is disrupted. In these disorders DDX23 interfaces with proteins such as PRPF8 highlighting its importance in maintaining cellular and organismal health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854182895785,"sku":"ab228999","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab228999","provider":"Iright","version":"1.0","type":"link"}