{"product_id":"abcam-ab229494","title":"Abcam, ab229494, Anti-MyT1L antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MYT1L antibody. Suitable for ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MYT1L.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MYT1L. The exact immunogen used to generate this antibody is proprietary information.Q9UL68\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMyT1L also known as Myelin Transcription Factor 1-like is a transcription factor with a mass of about 125 kDa. It functions mechanically as a DNA-binding protein regulating the expression of specific target genes. You will find MyT1L expressed in the central nervous system including the brain and spinal cord. Its expression also extends to other tissues but is lower compared to neural tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMyT1L plays a role in neuronal differentiation impacting the development of neural progenitor cells into mature neurons. It does not function as part of a larger protein complex. Instead MyT1L acts independently primarily controlling the transcriptional regulation of genes involved in neuronal development. Its action ensures proper neuronal specification and plasticity critical in forming functional neural networks.\u003cbr\u003e\nPathways\u003cbr\u003e\nMyT1L participates in neurogenesis and central nervous system development pathways. It interacts with proteins like MyT1 and other neurogenic factors orchestrating the intricate processes of neural lineage commitment. MyT1L's involvement in the Notch signaling pathway although less explored may coordinate with these proteins to regulate the fate of neural precursor cells.\u003cbr\u003e\nMyT1L shows links to neurological conditions such as epilepsy and intellectual disabilities. Changes in MyT1L expression or activity suggest potential disruptions in neural differentiation contributing to these disorders. In epilepsy for instance MyT1L might interact with proteins like MyT1 which could influence the electrical activity balance in neural circuits and lead to the disease pathology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854234407081,"sku":"ab229494","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab229494","provider":"Iright","version":"1.0","type":"link"}