{"product_id":"abcam-ab230114","title":"Abcam, ab230114, Anti-MEST antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal MEST antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MEST aa 100 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MEST aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q5EB52\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe 'MEST' protein also often referred to as the 'MEST band' is an imprinted gene product with molecular mass approximately 40 kDa. It displays biallelic and tissue-specific expression being especially present in tissues like placenta fetal tissues and adipose tissue. MEST also plays a critical role in development and metabolism providing an essential regulatory function in these tissues. The protein's expression levels can vary due to genomic imprinting which leads to selective expression from the paternal allele in certain contexts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe MEST protein participates in key cellular processes such as embryonic growth and adipocyte metabolism. It has a role in fetal development influencing growth rates and differentiation in tissues where it is expressed. If included in complex formations MEST may interact with other proteins to modulate signals that are important in these developmental processes. Given its involvement in adipogenesis MEST is also significant in energy homeostasis and fat storage impacting the body's metabolic responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe MEST protein integrates into the adipogenesis signaling pathway contributing to the formation and function of adipose tissue. Additionally MEST is implicated in the insulin signaling pathway linking it to glucose metabolism and insulin sensitivity. Through these pathways MEST engages with other proteins such as PPARγ (Peroxisome proliferator-activated receptor gamma) and CEBPα (CCAAT\/enhancer-binding protein alpha) which further highlights its involvement in regulating adipocyte differentiation and metabolic functions.\u003cbr\u003e\nAlterations in MEST expression levels associate with various metabolic syndromes such as obesity and type 2 diabetes. These conditions reveal how improper regulation of MEST can disrupt energy balance and glucose metabolism. Its link to PPARγ highlights a connection to lipid disorders as this protein is important for lipid metabolism and any dysregulation might contribute to the development of metabolic-related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854359122089,"sku":"ab230114","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab230114","provider":"Iright","version":"1.0","type":"link"}