{"product_id":"abcam-ab230369","title":"Abcam, ab230369, PD-1\/PD-L1 inhibitor 1, small molecule inhibitor","description":"\u003cp\u003eSize: 1mg \/ 5mg \/ 10mg \/ 25mg\u003cbr\u003e\nMW 475.6 Da, Purity \u0026gt;98%. PD-1\/PD-L1 inhibitor 1 blocks the PD-1\/PD-L1 interaction with an IC 50  of 6 nM in a cell-free HTRF assay.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1675201-83-8,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:475.6 Da,\u003cbr\u003e\nMolecular formula:C29H33NO5,\u003cbr\u003e\nPubChem:91663303,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:200 mM in DMSO200 mM in water200 mM in ethanol,\u003cbr\u003e\nBiochemical name:Pd-1\/pd-l1 inhibitor 1,\u003cbr\u003e\nBiological description:PD-1\/PD-L1 inhibitor 1 blocks the PD-1\/PD-L1 interaction with an IC50 of 6 nM in a cell-free HTRF assay.,\u003cbr\u003e\nCanonical smiles:CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C(=C3)OC)CN4CCCCC4C(=O)O)OC,\u003cbr\u003e\nIsomeric smiles:CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C(=C3)OC)CN4CCCC[C@H]4C(=O)O)OC,\u003cbr\u003e\nInChi:InChI=1S\/C29H33NO5\/c1-20-22(12-9-13-24(20)21-10-5-4-6-11-21)19-35-23-16-27(33-2)25(28(17-23)34-3)18-30-15-8-7-14-26(30)29(31)32\/h4-6,9-13,16-17,26H,7-8,14-15,18-19H2,1-3H3,(H,31,32)\/t26-\/m0\/s1,\u003cbr\u003e\nInChiKey:ZBOYJODMIAUJHH-SANMLTNESA-N,\u003cbr\u003e\nIUPAC Name:(2S)-1-[[2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPD-L1 also known as Programmed Death-Ligand 1 or CD274 is a protein involved in immune modulation. Mechanically PD-L1 interacts with its receptors particularly PD-1 to regulate cellular immune responses. This transmembrane protein has a calculated molecular weight of approximately 33 kDa. PD-L1 is expressed on various cell types including tumor cells and immune cells such as dendritic cells macrophages and B cells. Its expression is often upregulated in response to inflammatory cytokines.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPD-L1 plays a central role in immune evasion mechanisms utilized by tumors. It is not part of a larger protein complex but directly interacts with PD-1 and CD80. When PD-L1 binds to PD-1 it sends inhibitory signals leading to decreased T cell activation and proliferation allowing cancer cells to avoid immune destruction. PD-L1 expression provides a mechanism for tumors to suppress immune surveillance facilitating tumor progression.\u003cbr\u003e\nPathways\u003cbr\u003e\nPD-L1 is integral to the immune checkpoint pathway which is an important regulator of immune response. The interaction between PD-L1 and PD-1 provides a mechanism for immune tolerance which is part of the broader adaptive immune system pathway. PD-L1 is related to other immune checkpoint proteins such as CTLA-4 in its function to limit autoreactivity and promote immune homeostasis.\u003cbr\u003e\nPD-L1 is most associated with cancer particularly in tumors such as melanoma and non-small cell lung cancer. PD-L1 expression on tumor cells often correlates with poor prognosis. PD-L1 directly interacts with PD-1 in these cancers a target for immunotherapies such as checkpoint inhibitors which aim to block this interaction and restore immune activity against tumors. PD-L1 involvement extends to autoimmune disorders where altered expression can impact tolerance and lead to immune-related tissue damage.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847430852777,"sku":"ab230369","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab230369","provider":"Iright","version":"1.0","type":"link"}