{"product_id":"abcam-ab230375","title":"Abcam, ab230375, G10, STING signaling activator","description":"\u003cp\u003eSize: 1mg \/ 5mg \/ 10mg \/ 25mg\u003cbr\u003e\nMW 430.9 Da, Purity \u0026gt;98%. G10 is an indirect activator or stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs).  In vitro , it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC 90 s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:702662-50-8,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:430.9 Da,\u003cbr\u003e\nMolecular formula:C21H16ClFN2O3S,\u003cbr\u003e\nPubChem:5077622,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100mMSoluble in ethanol to 50 mM,\u003cbr\u003e\nBiochemical name:STING agonist-1,\u003cbr\u003e\nBiological description:G10 is an indirect activator or stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC90s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.,\u003cbr\u003e\nCanonical smiles:C1C(=O)N(C2=C(S1)C=CC(=C2)C(=O)NCC3=CC=CO3)CC4=C(C=CC=C4Cl)F,\u003cbr\u003e\nInChi:InChI=1S\/C21H16ClFN2O3S\/c22-16-4-1-5-17(23)15(16)11-25-18-9-13(6-7-19(18)29-12-20(25)26)21(27)24-10-14-3-2-8-28-14\/h1-9H,10-12H2,(H,24,27),\u003cbr\u003e\nInChiKey:NAGKYJATVFXZKN-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:4-[(2-chloro-6-fluorophenyl)methyl]-N-(furan-2-ylmethyl)-3-oxo-1,4-benzothiazine-6-carboxamide,\u003cbr\u003e\nExcitation\/Emission:Ex: 253nm, Em: 292nm\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847470370985,"sku":"ab230375","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab230375","provider":"Iright","version":"1.0","type":"link"}