{"product_id":"abcam-ab231963","title":"Abcam, ab231963, Anti-PYGM antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal PYGM antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Pygm aa 1-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Mouse Pygm aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q9WUB3\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPYGM also known as muscle glycogen phosphorylase or myophosphorylase is an enzyme with a molecular mass of around 97 kDa. This enzyme plays a mechanical role in glycogen metabolism by catalyzing the breakdown of glycogen to glucose-1-phosphate. PYGM is particularly expressed in skeletal muscles where it aids in mobilizing stored energy during periods of increased demand such as exercise.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe function of PYGM is critical in energy homeostasis within muscle tissue. This enzyme forms part of the glycogen phosphorylase complex which facilitates rapid energy release by converting glycogen into glucose-1-phosphate. This release is important for maintaining adequate levels of glucose for muscle contraction during activity or stress. Its activity is modulated by various factors including allosteric changes and phosphorylation processes ensuring that glucose metabolism aligns with the cellular energy requirements.\u003cbr\u003e\nPathways\u003cbr\u003e\nPYGM integrates mainly into the glycolytic pathway where it provides glucose-1-phosphate as a substrate for glycolysis enhancing ATP production. The enzyme also plays an important role in the glycogenolysis pathway orchestrating energy release from glycogen stores. PYGM functions in connection with related proteins such as glycogen debranching enzyme and phosphoglucomutase working in concert to maintain energy balance and inform the overall metabolic response during physical exertion.\u003cbr\u003e\nDefects in PYGM relate to McArdle disease a metabolic muscle disorder characterized by exercise intolerance and myoglobinuria. Deficiencies in PYGM impair glycogen breakdown in muscles leading to reduced availability of glucose for energy and resulting in muscle fatigue and pain. This disorder often links with metabolic consequences affecting enzymes involved in glucose handling such as muscle adenylate kinase highlighting the interconnected nature of metabolic pathways and disease pathology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848624361641,"sku":"ab231963","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab231963","provider":"Iright","version":"1.0","type":"link"}