{"product_id":"abcam-ab232158","title":"Abcam, ab232158, Anti-CCL4\/MIP-1 beta + CCL4L1 antibody [EPR494] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal CCL4\/MIP-1 beta antibody. Carrier free. Suitable for IP, ICC\/IF, WB and reacts with Human, Recombinant fragment - Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR494,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab232158 is the carrier-free version of\u003cbr\u003e\nab40857\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCCL4 also known as MIP-1 beta and CCL4L1 are chemokines involved in immune responses. These proteins weigh approximately 7.8 kDa. CCL4 and CCL4L1 are expressed in various tissues including lymphoid organs activated T cells and macrophages. Their expression occurs in response to inflammatory signals contributing to the attraction and activation of specific immune cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe chemokines CCL4 and its homolog CCL4L1 play important roles in immune cell trafficking and coordination of the inflammatory response. They are involved in recruiting monocytes natural killer cells and various types of T cells to sites of inflammation. CCL4 and CCL4L1 function as part of a larger chemokine system interacting with receptors such as CCR5 to modulate immune responses effectively.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe chemokines CCL4 and CCL4L1 feature prominently in the immune signaling pathway and the MAPK pathway. These pathways regulate immune responses and cell survival. Their interaction with receptor CCR5 links them to other chemokines like CCL3 which also utilizes CCR5. This signaling cascade influences cellular responses essential for proper immune system functioning.\u003cbr\u003e\nCCL4 and CCL4L1 play roles in HIV infection and rheumatoid arthritis. They affect HIV progression by binding to the CCR5 receptor which the virus uses to enter host cells. In rheumatoid arthritis they contribute to synovial inflammation through recruitment of inflammatory cells. These interactions highlight their connection with other proteins like HIV-1 gp120 and CCR5 in HIV and TNF-alpha in rheumatoid arthritis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851836215465,"sku":"ab232158","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab232158","provider":"Iright","version":"1.0","type":"link"}