{"product_id":"abcam-ab232475","title":"Abcam, ab232475, Anti-RBM6 antibody [EPR15842] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal RBM6 antibody. Carrier free. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15842,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab232475 is the carrier-free version of\u003cbr\u003e\nab188318\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRBM6 also known as RNA binding motif protein 6 plays a significant role in RNA binding activities. It exhibits a molecular mass of approximately 94 kDa. This protein is expressed in a variety of tissues with higher expression levels observed in the lung and brain. RBM6 contains several RNA recognition motifs that facilitate its involvement in the regulation of RNA processing including splicing stability and transport.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRNA binding motif protein 6 contributes to the regulation of gene expression by interacting with specific RNA sequences. It often functions as part of a larger ribonucleoprotein complex. Through its interactions RBM6 influences alternative splicing events which modify mRNA precursors to create diverse protein isoforms. This activity is essential for the cellular response to different physiological conditions and RBM6 has been implicated in cell cycle regulation and apoptosis.\u003cbr\u003e\nPathways\u003cbr\u003e\nRNA binding motif protein 6 is involved in several important cellular processes. It is an important component of the splicing machinery and participates in the spliceosome pathway interacting with other splicing factors like SF3B1 and SRSF2. Additionally RBM6 has links to the RNA transport pathway influencing the export of mature mRNAs from the nucleus to the cytoplasm where translation occurs.\u003cbr\u003e\nAlterations in RNA binding motif protein 6 can impact oncogenesis and neurological conditions. Abnormal expression of RBM6 has been observed in certain cancers such as lung cancer where it may cooperate with or have effects opposite to tumor suppressor proteins like RBM5. Furthermore mutations or dysregulation of RBM6 might affect neural development or function suggesting a possible connection to neurodegenerative disorders where it could interact with genes involved in neuronal survival and degeneration.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851860136105,"sku":"ab232475","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab232475","provider":"Iright","version":"1.0","type":"link"}