{"product_id":"abcam-ab232632","title":"Abcam, ab232632, Anti-JAML antibody [EPR15289] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal JAML antibody. Carrier free. Suitable for IP, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15289,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab232632 is the carrier-free version of\u003cbr\u003e\nab183714\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein JAML also referred to as Junctional Adhesion Molecule-Like is an important transmembrane protein with a molecular mass of approximately 36 kDa. It belongs to the immunoglobulin superfamily and functions in the immune response. JAML is widely expressed in epithelial cells and various immune cells particularly in neutrophils and some subsets of T cells. On a cellular level JAML is involved in cell-cell adhesion processes functioning at interfaces where immune cells interact with epithelial layers.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nBeyond serving as a simple structural component JAML establishes interactions critical for immune surveillance and cell movement. It pairs with other immune receptors to promote the transmigration of leukocytes across endothelial and epithelial barriers. This interaction is notably important since JAML mediates adhesion through its engagement with the Coxsackievirus and Adenovirus Receptor (CAR) forming dynamic complexes that facilitate immune cell trafficking.\u003cbr\u003e\nPathways\u003cbr\u003e\nMany cellular processes engage JAML in key signaling pathways responsible for immune responses. The protein takes part in the integrin signaling pathway affecting cellular adhesion and migration. Additionally JAML interacts with LFA-1 (Lymphocyte Function-associated Antigen 1) an integrin involved in leukocyte function modulating pathways that govern immune cell behavior and inflammation responses.\u003cbr\u003e\nThe functional role of JAML becomes particularly significant in contexts of inflammatory conditions and cancer. Inflammatory diseases such as inflammatory bowel disease (IBD) show considerable involvement of JAML as its regulatory influence on leukocyte transmigration exacerbates inflammation. Similarly changes in JAML expression have implications in cancer metastasis mechanisms as they relate to immune evasion in tumors. In these conditions JAML interacts closely with proteins like CAR and LFA-1 linking its expression and activity directly to disease progression and immune response modulation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851923476649,"sku":"ab232632","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab232632","provider":"Iright","version":"1.0","type":"link"}