{"product_id":"abcam-ab232899","title":"Abcam, ab232899, Anti-IFNA4 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal IFNA4 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human IFNA4 aa 1 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human IFNA4 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P05014\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe IFNA4 gene encodes a member of the alpha interferon family commonly known as Interferon alpha-4 (IFN-α4). This protein plays an important role in the immune response acting as a signaling molecule that helps regulate the activity of the immune system. IFN-α4 consists of approximately 20 kilodaltons in mass. It is expressed in various tissues but is most abundant in blood cells and at sites of infection or inflammation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nInterferon alpha-4 engages in antiviral defense mechanisms by binding to specific receptors on the surface of cells triggering a cascade of cellular responses to represent an antiviral state. This state restricts viral replication within host cells. IFN-α4 forms part of a diverse family of cytokines known as type I interferons. These cytokines all share the common mechanism of activating immune responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe involvement of interferon alpha-4 in the Jak-STAT pathway is significant for transducing signals that lead to the expression of interferon-stimulated genes (ISGs). It closely interacts with other proteins like STAT1 and STAT2 which play important roles in this signaling cascade. By triggering these pathways IFN-α4 and related proteins contribute to the host's defense against infections.\u003cbr\u003e\nAbnormalities in IFN-α4 expression or function can relate to autoimmune diseases such as Systemic Lupus Erythematosus (SLE) where excessive interferon activity can damage tissues. Chronic Hepatitis C infection is another condition linked to this protein where altered IFN-α responsiveness complicates viral clearance. IFN-α4's interactions with other cytokines such as IFN-β may also influence the disease states and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854248497321,"sku":"ab232899","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab232899","provider":"Iright","version":"1.0","type":"link"}