{"product_id":"abcam-ab234231","title":"Abcam, ab234231, PE Anti-DR3\/LARD antibody [JD3]","description":"\u003cp\u003eSize: 100Test\u003cbr\u003e\nMouse Monoclonal DR3\/LARD antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TNFRSF25.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:JD3,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nConjugation:PE,\u003cbr\u003e\nExcitation\/Emission:Ex: 480;565nm, Em: 578nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human TNFRSF25. The exact immunogen used to generate this antibody is proprietary information.Q93038\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Size-exclusion chromatography, Purification notes-ab234231 is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use., Storage buffer-pH: 7.4Preservative: 0.0975% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe DR3 receptor also known as LARD (Lymphocyte Apoptosis-Related Receptor Domain) is a member of the TNF receptor superfamily. This protein also referred to as the DR3 protein or LARD protein is involved in mediating apoptotic signals. DR3 is expressed predominantly in lymphoid tissues and plays an important role in immune system regulation. DR3 protein has an approximate mass of 65 kDa. Scientists study DR3 in various models including cyno RNA and protein monkey models to gain better understanding of its function and expression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDR3 functions significantly in the immune response by modulating apoptosis. It forms part of a complex with other proteins leading to the activation of signaling pathways that result in cell death. The binding of its ligand TL1A to DR3 initiates a series of downstream effects that influence T-cell and other immune cell activities. LARD target has a functional correlation with the regulation of immune response and the maintenance of homeostasis in immune cell populations.\u003cbr\u003e\nPathways\u003cbr\u003e\nDR3 receptor mediates signals primarily in two significant pathways: the NF-kB pathway and the MAPK pathway. These pathways play a role in transducing signals that lead to inflammation and immune responses. DR3 interacts with other proteins such as TRADD and RIPK1 facilitating the propagation of signals through these pathways. The engagement of DR3 in these pathways highlights its regulatory influence over immune cell survival and function.\u003cbr\u003e\nDR3 plays an important role in autoimmune diseases and inflammatory disorders. Dysregulation of DR3 receptor and its signaling pathways can contribute to conditions like rheumatoid arthritis and inflammatory bowel disease. There is a notable connection between dysfunction in DR3 signaling and altered interactions with pro-inflammatory proteins such as TNF-alpha which can exacerbate these conditions. Understanding DR3's role helps in developing therapeutic approaches to manage these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854784221353,"sku":"ab234231","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab234231","provider":"Iright","version":"1.0","type":"link"}