{"product_id":"abcam-ab234278","title":"Abcam, ab234278, APC Anti-DEP1 antibody [MEM-CD148\/05]","description":"\u003cp\u003eSize: 100Test\u003cbr\u003e\nMouse Monoclonal DEP1 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PTPRJ aa 1-450.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:MEM-CD148\/05,\u003cbr\u003e\nIsotype:IgG2b,\u003cbr\u003e\nConjugation:APC,\u003cbr\u003e\nExcitation\/Emission:Ex: 650nm, Em: 660nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PTPRJ aa 1-450. The exact immunogen used to generate this antibody is proprietary information.Q12913\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Size-exclusion chromatography, Purification notes-ab234278 is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use., Storage buffer-pH: 7.4Preservative: 0.0975% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze, Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDEP1 also known as protein tyrosine phosphatase receptor type J (PTPRJ) is an important regulator in cell signaling. Its molecular mass is approximately 135-150 kDa. DEP1 is a transmembrane protein expressed in many tissues like epithelial cells endothelial cells and hematopoietic cells. It functions as a protein tyrosine phosphatase meaning it removes phosphate groups from tyrosine residues on target proteins which impacts many cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDEP1 acts as a negative regulator of cell proliferation differentiation and migration. It plays a role in maintaining cellular homeostasis and is often found in complex with other signaling molecules at cell-cell junctions. DEP1 modulates signaling pathways by dephosphorylating receptor tyrosine kinases or their downstream targets. This regulation impacts how cells respond to external stimuli and maintain normal physiological activities.\u003cbr\u003e\nPathways\u003cbr\u003e\nDEP1 is active in both the RAS\/MAPK signaling pathway and the PI3K\/AKT pathway. It interacts with signaling molecules such as epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) impacting their signaling abilities. By dephosphorylating these receptors DEP1 modulates the pathways that control cell growth and survival influencing how cells react to growth factors and other signals.\u003cbr\u003e\nDEP1 connects to several cancers and cardiovascular diseases. It often acts as a tumor suppressor by inhibiting signaling pathways that promote uncontrolled cell growth. In cancer altered DEP1 expression or function can lead to changes in cellular behaviors contributing to tumorigenesis. It relates to proteins like VEGFR in these contexts as their dysregulation can lead to abnormal vascularization in tumors and in cardiovascular disease affecting angiogenesis and blood vessel integrity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855480836265,"sku":"ab234278","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab234278","provider":"Iright","version":"1.0","type":"link"}