{"product_id":"abcam-ab234568","title":"Abcam, ab234568, Human PDGF-CC ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman PDGF-CC ELISA Kit is a single-wash 90-min Simplestep used to quantify Human PDGF-CC with a sensitivity of 2.79 pg\/ml. The assay uses a simple mix-wash-read protocol with just one incubation and one wash step. - Colorimetric Sandwich ELISA - 450 nm readout : works on any standard plate reader - Design your own immunoassay: we also offer the conjugation-ready antibody pair\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Citrate plasma, Cell culture supernatant, Serum,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 2.79 pg\/mL,\u003cbr\u003e\nRange:28.125 - 1800 pg\/mL,\u003cbr\u003e\nAssay time:1h 30m,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHuman PDGF-CC ELISA Kit (ab234568) is a single-wash 90 min sandwich ELISA designed for the quantitative measurement of PDGF-CC protein in cell culture supernatant, cit plasma, and serum. It uses our proprietary SimpleStep ELISA® technology. Quantitate Human PDGF-CC with 2.79 pg\/ml sensitivity.\u003cbr\u003e\nSimpleStep ELISA® technology employs capture antibodies conjugated to an affinity tag that is recognized by the monoclonal antibody used to coat our SimpleStep ELISA® plates. This approach to sandwich ELISA allows the formation of the antibody-analyte sandwich complex in a single step, significantly reducing assay time. See the SimpleStep ELISA® protocol summary in the image section for further details. Our SimpleStep ELISA® technology provides several benefits:\u003cbr\u003e\n- Single-wash protocol reduces assay time to 90 minutes or less\u003cbr\u003e\n- High sensitivity, specificity and reproducibility from superior antibodies\u003cbr\u003e\n- Fully validated in biological samples\u003cbr\u003e\n- 96-wells plate breakable into 12 x 8 wells strips\u003cbr\u003e\nA 384-well SimpleStep ELISA® microplate (\u003cbr\u003e\nab203359\u003cbr\u003e\n) is available to use as an alternative to the 96-well microplate provided with SimpleStep ELISA® kits.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPlatelet-Derived Growth Factor CC (PDGF-CC) is a member of the PDGF family consisting of homodimeric and heterodimeric isoforms. PDGF-CC with a mass of approximately 44 kDa partakes in various cellular processes. It primarily expresses in fibroblasts endothelial cells and some types of neurons. PDGF-CC functions by binding to tyrosine kinase receptors specifically PDGFRαα and PDGFRαβ where it triggers intracellular signaling pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPDGF-CC influences cell proliferation migration and survival particularly in the context of vascular development and remodeling. It acts as a powerful growth factor for mesenchymal cells and plays a role in embryonic development. PDGF-CC forms a functional complex after proteolytic activation which is essential for its receptor-binding capacity. This factor significantly regulates angiogenesis and wound healing processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nPDGF-CC is integral to the PDGF signaling pathway and is involved in the PI3K\/AKT signaling pathway. These pathways promote cellular growth survival and proliferation. PDGF-CC's interaction with PDGF receptors primarily PDGFRα facilitates these biological functions. In these pathways PDGF-CC interacts with other proteins such as PI3K and AKT connecting it to broader cellular response networks.\u003cbr\u003e\nPDGF-CC has been associated with fibrotic diseases and certain cancers. Its overexpression or dysregulation can contribute to pathological fibrosis through excessive tissue repair. PDGF-CC is also linked to glioblastoma a type of brain cancer where abnormal PDGF signaling leads to tumor progression. PDGF-CC interacts with PDGFRα in these disease contexts highlighting its contribution to disease mechanisms when dysregulated.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843570847913,"sku":"ab234568","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab234568","provider":"Iright","version":"1.0","type":"link"}