{"product_id":"abcam-ab234669","title":"Abcam, ab234669, Anti-TSSC3 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TSSC3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PHLDA2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human PHLDA2.Q53GA4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTSSC3 also known as Tumor Suppressor Candidate 3 encodes a protein with a molecular weight of approximately 25 kDa. This protein is encoded by a gene located on human chromosome 11. TSSC3 undergoes expression in various tissues with high levels in the placenta and kidney. The protein functions as a pro-apoptotic factor playing a role in promoting apoptosis by influencing mitochondrial membrane potential and cytochrome c release.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein encoded by TSSC3 acts in cellular processes that regulate apoptosis which is a mechanism of programmed cell death essential for maintaining cellular homeostasis. Though not part of a larger protein complex TSSC3 interacts with other mitochondrial proteins to execute its function as an apoptosis promoter. Its role in apoptosis suggests its importance in developmental processes and in the elimination of damaged cells thereby contributing to tissue health.\u003cbr\u003e\nPathways\u003cbr\u003e\nTSSC3 modulates cellular apoptosis pathways including the intrinsic apoptotic pathway. Within these pathways TSSC3 interacts with proteins like BAX and BAK which influence mitochondrial membrane integrity and cytochrome c release. Through these interactions TSSC3 helps regulate the balance between cell survival and death influencing cell fate decisions in response to various stimuli.\u003cbr\u003e\nTSSC3 has known associations with several cancers including Wilms' tumor and choriocarcinoma due to its tumor suppressor properties. When TSSC3 function is impaired or its expression reduced there is evidence suggesting an increase in tumorigenic activities. The relationship between TSSC3 and the p53 protein an important tumor suppressor further supports its role in cancer as they both influence apoptotic pathways that suppress abnormal cell proliferation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850136965289,"sku":"ab234669","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab234669","provider":"Iright","version":"1.0","type":"link"}