{"product_id":"abcam-ab234670","title":"Abcam, ab234670, Anti-PKD1L3 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal PKD1L3 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PKD1L3 aa 1-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PKD1L3 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q7Z443\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPKD1L3 also known as Polycystic Kidney Disease 1-Like 3 is a protein involved in mechanosensation and ion channel activity. It has an estimated molecular mass of approximately 250 kDa. PKD1L3 is part of the TRPP channel family and is known for forming channels with the related protein PKD2L1. Expression of PKD1L3 occurs in various tissues including the tongue where it participates in taste perception processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein functions as a subunit of a nonselective ion channel complex that contributes to sensory functions. PKD1L3 together with PKD2L1 forms ion channels that respond to environmental changes including pH alterations. This tetrameric channel complex plays a role in taste perception and is known to mediate sour taste reception in taste cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearchers have found that PKD1L3 participates in the sensory transduction pathway specifically in taste reception. It works closely with PKD2L1 to form functional complexes essential for sour taste perception. The involvement of PKD1L3 in these pathways along with its interaction with PKD2L1 highlights its role in signal transduction processes related to sensory perception.\u003cbr\u003e\nPKD1L3 relates to polycystic kidney disease and taste disorders. Mutations or alterations in PKD1L3 along with PKD2L1 may contribute to these conditions impacting normal function and potentially leading to sensory deficits or pathological kidney functions. The connection between PKD1L3 and PKD2L1 highlights their combined influence in these conditions providing insights into potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854207111337,"sku":"ab234670","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab234670","provider":"Iright","version":"1.0","type":"link"}