{"product_id":"abcam-ab234722","title":"Abcam, ab234722, Anti-TAF2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TAF2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TAF2 aa 400-450.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human TAF2 aa 400-450. The exact immunogen used to generate this antibody is proprietary information.Q6P1X5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTAF2 also known as Transcription Initiation Factor TFIID Subunit 2 is a component of the basal transcription factor TFIID complex. This protein has a mass of approximately 141 kDa. It is expressed in several tissues including the liver lung and brain indicating its widespread importance in cellular functions. TAF2 has a role in recognizing the promoter sequences and facilitating the assembly of the transcription machinery. It helps with the recruitment of RNA polymerase II and other general transcription factors to genes that are transcribed by this polymerase.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTAF2 helps in transcription initiation through its function as part of the TFIID complex. TFIID consists of the TATA-binding protein (TBP) and several associated factors including TAF2 which contribute to promoter recognition. In this context TAF2 assists in stabilizing the interaction of TFIID with specific promoters. This function positions TFIID as a scaffold upon which other transcriptional complexes assemble facilitating the start of mRNA synthesis. Therefore TAF2 is involved in adjusting the basal transcriptional level of RNA polymerase II-dependent genes.\u003cbr\u003e\nPathways\u003cbr\u003e\nTAF2 plays a significant role in the transcriptional regulatory networks. It is an essential component in the RNA polymerase II transcription initiation pathway and also influences gene expression in response to extracellular signals. The protein works closely with other TAFs and TBP within the pathway. Additionally TAF2 interacts with several signal transduction pathways through its involvement in mediating transcriptional responses ensuring proper cellular function and response to environmental changes.\u003cbr\u003e\nTAF2 has associations with transcription-related disorders and certain cancers. Dysregulation of TAF2 function contributes to tumor development and progression. In some cancers altered expression of TAF2 affects the transcriptional networks leading to abnormal cell growth. It is also connected to disorders related to transcription malfunction often through interactions with proteins like TAF1 and TBP both key regulators of transcription. Understanding TAF2's role can aid in developing targeted therapies for such conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854350176425,"sku":"ab234722","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab234722","provider":"Iright","version":"1.0","type":"link"}