{"product_id":"abcam-ab234873","title":"Abcam, ab234873, Anti-ATP9A antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal ATP9A antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ATP9A aa 1-100.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human ATP9A aa 1-100. The exact immunogen used to generate this antibody is proprietary information.O75110\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nATP9A also known as ATPase phospholipid transporting 9A is a protein that acts as a phospholipid flippase involved in the movement of phospholipids across cellular membranes. This protein has a mass of approximately 125 kDa and is expressed in various tissues with notable presence in the brain and liver. ATP9A contains important structural domains that enable it to bind and hydrolyze ATP driving the translocation of phospholipids to maintain the asymmetry of lipid bilayers.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe ATP9A protein plays an important role in membrane trafficking processes which are essential for proper cellular communication and cargo transport. It does not operate alone; ATP9A often associates with other cellular components to drive vesicular trafficking events. The protein is vital in endosomal sorting contributing to the correct targeting of proteins and lipids within cells. Dysregulation in its activity can disrupt these processes pointing to its importance in maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe functions of ATP9A integrate into mechanisms like endocytosis and phospholipid metabolism. It has a connection with the phosphatidylinositol signalling pathway which is critical for vesicle transport and membrane dynamics. ATP9A interacts with proteins such as Rab11 a small GTPase involved in recycling endosomes reflecting its importance in endocytic recycling processes. These interconnected activities demonstrate ATP9A's role in regulating intracellular lipid distribution and movement.\u003cbr\u003e\nATP9A is particularly significant in oncological and neurological contexts. Alterations in its expression or function have been linked to cancer progression due to changes in cell migration and invasion linked to phospholipid dysregulation. Furthermore its involvement in proper neuromodulation in the brain connects ATP9A to neurodegenerative diseases. Relatedly ATP9A influences the activity of SNARE proteins important for synaptic vesicle fusion highlighting its broader impact on synaptic health and pathology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854198886569,"sku":"ab234873","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab234873","provider":"Iright","version":"1.0","type":"link"}