{"product_id":"abcam-ab234885","title":"Abcam, ab234885, Anti-PHLDB2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal PHLDB2 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PHLDB2 aa 700-1050.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PHLDB2 aa 700-1050. The exact immunogen used to generate this antibody is proprietary information.Q86SQ0\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein PHLDB2 also known as pleckstrin homology-like domain family B member 2 plays important mechanical roles in cellular signaling and structural processes. It weighs around 122 kDa and expresses in various tissues including the brain and immune cells. PHLDB2 interacts with the plasma membrane through its pleckstrin homology domain playing a regulatory role in cytoskeletal arrangements and cellular adhesion.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein interacts within cellular environments to modulate cell polarity and migration often involving complex formations. PHLDB2 associates with actin filaments and contributes to directed cell movement. It helps regulate immune responses by influencing antibody production and cell surface receptor dynamics impacting how cells respond to external signals.\u003cbr\u003e\nPathways\u003cbr\u003e\nPHLDB2 participates actively in the PI3K\/AKT signaling pathway and cytoskeleton regulation. It partners with other proteins like AKT to control cell growth survival and metabolism. The protein also interacts within the Wnt signaling pathway aiding in further modulation of cellular polarization and movement linking it to cell fate decisions in development.\u003cbr\u003e\nPHLDB2 is linked to glioblastoma and systemic lupus erythematosus through its influence on cellular migration and immune regulation. In glioblastoma aberrant expression levels of PHLDB2 affect tumor cell invasion and metastasis often involving interactions with proteins such as integrins. In systemic lupus erythematosus PHLDB2 dysregulation impacts immune cell functions and inflammatory responses connecting to proteins like IL-6 in the immune signaling pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854163136681,"sku":"ab234885","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab234885","provider":"Iright","version":"1.0","type":"link"}