{"product_id":"abcam-ab235500","title":"Abcam, ab235500, RG-7112, MDM2 inhibitor","description":"\u003cp\u003eSize: 5mg\u003cbr\u003e\nMW 727.8 Da, Purity \u0026gt;98%. Potent, orally bioavailable MDM2 inhibitor that displays antineoplastic activity. Nutlin imidazoline compound. RG-7112 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. Binds MDM2 with K D  = 10.7 nM. Blocks the p53- MDM2 interaction with an IC 50  of 18 nM in HTRF assays.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:939981-39-2,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:727.8 Da,\u003cbr\u003e\nMolecular formula:C38H48Cl2N4O4S,\u003cbr\u003e\nPubChem:57406853,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:DMSO 100 mg\/mL (138 mM)Ethanol 100 mg\/mL (138 mM)Insoluble in water,\u003cbr\u003e\nBiochemical name:Unii-Q8MI0X869M,\u003cbr\u003e\nBiological description:Potent, orally bioavailable MDM2 inhibitor that displays antineoplastic activity. Nutlin imidazoline compound. RG-7112 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. Binds MDM2 with KD = 10.7 nM. Blocks the p53- MDM2 interaction with an IC50 of 18 nM in HTRF assays.,\u003cbr\u003e\nCanonical smiles:CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl,\u003cbr\u003e\nIsomeric smiles:CCOC1=C(C=CC(=C1)C(C)(C)C)C2=N[C@@]([C@@](N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl,\u003cbr\u003e\nInChi:InChI=1S\/C38H48Cl2N4O4S\/c1-8-48-33-26-29(36(2,3)4)14-19-32(33)34-41-37(5,27-10-15-30(39)16-11-27)38(6,28-12-17-31(40)18-13-28)44(34)35(45)43-23-21-42(22-24-43)20-9-25-49(7,46)47\/h10-19,26H,8-9,20-25H2,1-7H3\/t37-,38+\/m0\/s1,\u003cbr\u003e\nInChiKey:QBGKPEROWUKSBK-QPPIDDCLSA-N,\u003cbr\u003e\nIUPAC Name:[(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazol-1-yl]-[4-(3-methylsulfonylpropyl)piperazin-1-yl]methanone\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B1919 RG-7112. B1919-5 is the same size as the 5 mg size of ab235500.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this is air sensitive and impurities can occur as a result of air oxidation, Store in the dark, Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847496749225,"sku":"ab235500","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab235500","provider":"Iright","version":"1.0","type":"link"}