{"product_id":"abcam-ab236173","title":"Abcam, ab236173, Recombinant Human XPC protein (His tag)","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Human XPC protein (His tag) is a Human Fragment protein, in the 496 to 734 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q01831,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.2 - 7.4Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Xeroderma Pigmentosum Complementation Group C (XPC) protein is essential for the nucleotide excision repair (NER) mechanism repairing DNA damage. XPC with a molecular weight of approximately 125 kDa recognises and binds to damaged DNA that has bulky adducts. It is expressed in various human tissues with higher expression levels in proliferating cells and skin. XPC plays a critical role in DNA testing and maintenance making it vital for maintaining genome stability.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe XPC protein acts as a damage sensor within the NER pathway and functions as part of the XPC-HR23B complex. This complex identifies DNA helix distortions and signals for repair by recruiting other proteins to the damage site. XPC functions by unwinding the DNA and allowing necessary repair enzymes such as DNA helicases and nucleases to perform their functions. This repair process ensures that the DNA is intact and capable of proper transcription and cell replication.\u003cbr\u003e\nPathways\u003cbr\u003e\nXPC operates within the nucleotide excision repair pathway which is essential for removing a wide range of DNA lesions caused by ultraviolet (UV) irradiation and chemical agents. It operates in conjunction with proteins such as XPA RPA and the TFIIH complex to execute DNA repair. XPC is also linked to the global genomic repair sub-pathway of NER where it plays a leading role in identifying DNA damage across the entire genome.\u003cbr\u003e\nIneffective XPC function is associated with Xeroderma Pigmentosum (XP) a genetic disorder causing extreme sensitivity to UV light and increased skin cancer risk. Mutations in the XPC gene impede DNA repair efficiency leading to the accumulation of damage. XPC is also connected to skin cancer development as its malfunction can cause failure to repair UV-induced lesions. Other proteins like XPA and XPE also show connections to these disorders highlighting their critical roles in maintaining DNA integrity and preventing disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843907899561,"sku":"ab236173","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab236173","provider":"Iright","version":"1.0","type":"link"}