{"product_id":"abcam-ab236741","title":"Abcam, ab236741, Anti-Kyphoscoliosis peptidase antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Kyphoscoliosis peptidase antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KY aa 1-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human KY aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q8NBH2\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity \u0026gt;95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKyphoscoliosis peptidase also known as ADAMTS-like protein 2 is a metalloproteinase. This protein family includes enzymes that break down extracellular matrix components. Kyphoscoliosis peptidase has a mass of around 130 kDa and is involved in the processing of several structural molecules. It is primarily expressed in tissues like skin tendon and cartilage indicating its main physiological roles. Its expression in these dense connective tissues suggests it plays a role in structural integrity and remodeling of the extracellular matrix.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nKyphoscoliosis peptidase contributes to maintaining the elastic properties of connective tissues. It assists in the proper organization and assembly of collagen fibrils by processing precursor molecules part of its enzymatic function. This protein may interact with other components of the extracellular matrix such as fibronectin or proteoglycans suggesting its involvement in a larger molecular complex. This activity is important in tissues undergoing constant mechanical stress and requiring elasticity.\u003cbr\u003e\nPathways\u003cbr\u003e\nKyphoscoliosis peptidase participates in the regulation of collagen biosynthesis and extracellular matrix remodeling. The protein is specifically involved in TGF-beta signaling pathways which regulate cellular differentiation and tissue homeostasis. It also affects the BMP signaling pathways influencing developmental processes and tissue repair. During these pathways Kyphoscoliosis peptidase interacts with other molecules like collagen type I and type VI integrating into broader biological contexts.\u003cbr\u003e\nKyphoscoliosis peptidase perturbations associate primarily with Ehlers-Danlos syndrome a connective tissue disorder resulting in joint hypermobility and skin elasticity. Alterations in its function also relate to kyphoscoliotic EDS a subtype characterized by severe skeletal abnormalities. In these conditions its interaction with proteins like type VI collagen becomes disrupted further affecting connective tissue structure and highlighting its significance in maintaining tissue integrity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854222741673,"sku":"ab236741","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab236741","provider":"Iright","version":"1.0","type":"link"}