{"product_id":"abcam-ab23691","title":"Abcam, ab23691, Anti-15-LOX-2 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal 15-LOX-2 antibody. Suitable for WB and reacts with Human, Pig samples. Cited in 19 publications. Immunogen corresponding to Synthetic Peptide within Human ALOX15B aa 150-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Pig,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ALOX15B aa 150-200. The exact immunogen used to generate this antibody is proprietary information.O15296\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-This antibody was affinity purified., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 50% Glycerol (glycerin, glycerine), 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\n15-LOX-2 also known as 15-lipoxygenase-2 is an enzyme that catalyzes the conversion of arachidonic acid to 15-hydroperoxyicosatetraenoic acid (15-HPETE). Its molecular mass is roughly 76 kDa. 15-LOX-2 is expressed in various tissues with high presence in the prostate lungs and skin. This enzyme is also detected in certain epithelial tissues suggesting its involvement in cellular processes related to skin and prostate health.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\n15-LOX-2 plays roles in lipid metabolism by catalyzing specific biochemical reactions. It helps in regulating inflammation through its metabolites. While not part of a larger enzyme complex 15-LOX-2 works alongside other lipoxygenases to manage lipid signaling molecules. Its function further influences cellular differentiation and apoptosis offering an important connection to tissue homeostasis and cellular turnover rates.\u003cbr\u003e\nPathways\u003cbr\u003e\n15-LOX-2 contributes to the arachidonic acid metabolic pathway and eicosanoid signaling pathways. It interacts with cyclooxygenases and other lipoxygenases within these pathways. This interaction affects the balance of pro-inflammatory and anti-inflammatory mediators. The enzyme's activity relates specifically to eicosanoids like leukotrienes and prostaglandins which influence immune responses and vascular functions.\u003cbr\u003e\n15-LOX-2 shows involvement in prostate cancer and atherosclerosis. Its regulation of inflammatory mediators suggests a role in inflammation-associated pathologies. In prostate cancer altered expression of 15-LOX-2 links to tumor progression interacting with enzymes like COX-2. In atherosclerosis dysregulation of its activity may lead to abnormal lipid metabolism and vessel inflammation demonstrating its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848648609961,"sku":"ab23691","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab23691","provider":"Iright","version":"1.0","type":"link"}