{"product_id":"abcam-ab237009","title":"Abcam, ab237009, Anti-TOX antibody [NAN448B]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nAnti-TOX antibody [NAN448B] (ab237009) is a rat monoclonal antibody detecting TOX in  Western Blot, IHC-P, IHC-Fr . Suitable for  Human, Mouse . - KO validated for confirmed specificity\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rat,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:NAN448B,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human, Cat, Dog, Horse, Pig, Llama, Cow, Goat, Sheep, Pigeon, Serinus canarius,\u003cbr\u003e\nApplications:IHC-Fr, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human TOX aa 1-250. The exact immunogen used to generate this antibody is proprietary information.O94900\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-TOX antibody [NAN448B] (ab237009) is a rat monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr) in Human, Mouse samples.\u003cbr\u003e\nWhat is the molecular weight of TOX?\u003cbr\u003e\nAnti-TOX [NAN448B] (ab237009) specifically detects a band for TOX (UniProt: O94900) at a molecular weight of 58kDa.\u003cbr\u003e\nSpecificity confirmed\u003cbr\u003e\nThe specificity of Anti-TOX antibody [NAN448B] (ab237009) has been confirmed by Western blot testing in TOX Knockout MOLT 4 cells.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe TOX gene encodes the TOX protein also known as Thymocyte selection-associated high mobility group (HMG) box protein with a molecular weight of approximately 57 kDa. TOX contains a DNA-binding HMG box domain and operates mechanically as a transcription factor. It expresses mainly in the thymus where it plays a significant role in T cell development. TOX also exhibits expression in lymphoid tissues including the spleen and lymph nodes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTOX affects T cell maturation and development particularly during thymocyte selection. The protein contributes critically to the decision-making process that determines whether thymocytes become CD4+ or CD8+ T cells. TOX does not assemble into a known complex but interacts with other developmental transcription factors to influence gene expression patterns in immature T cells. Its expression is tightly regulated to ensure proper immune system development.\u003cbr\u003e\nPathways\u003cbr\u003e\nTOX influences key signal transduction pathways that guide T cell lineage development. It integrates into the T cell receptor (TCR) signaling pathway impacting the expression of genes essential for T cell differentiation. TOX interacts with signaling proteins like Notch1 which affects developmental fate decisions in thymocytes. The balance of these pathways maintains immunity homeostasis and correct immune responses.\u003cbr\u003e\nTOX links to conditions involving immune dysregulation such as autoimmune diseases and certain lymphomas. Aberrant expression or dysfunction of TOX may contribute to improper immune cell development leading to pathologies like T cell leukemia. In autoimmune diseases altered TOX levels may impact self-tolerance involving proteins such as FOXP3 which governs regulatory T cell function. Understanding TOX's role in these diseases broadens insights into potential therapeutic targets for immune-related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860544540841,"sku":"ab237009","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab237009","provider":"Iright","version":"1.0","type":"link"}