{"product_id":"abcam-ab237682","title":"Abcam, ab237682, Anti-STRBP antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal STRBP antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STRBP aa 200-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human STRBP aa 200-500. The exact immunogen used to generate this antibody is proprietary information.Q96SI9\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSTRBP also referred to as Spermatid Perinuclear RNA Binding Protein is a protein with a molecular mass of approximately 75 kDa. STRBP binds to RNA and has been identified as having a role in the regulation of RNA metabolism. The protein shows enriched expression in the testis suggesting a role in spermatogenesis. STRBP also contains distinct RNA-binding domains which help in its interactions with various RNA molecules in the cellular environment.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSTRBP participates in processes linked to RNA stabilization and processing. It acts in the formation of ribonucleoprotein complexes within the cell interacting with specific RNA substrates to influence their structure and function. The protein's localization in the testis hints at its involvement in the development or function of sperm cells. Evidence suggests that STRBP contributes to post-transcriptional regulation impacting gene expression at the RNA level.\u003cbr\u003e\nPathways\u003cbr\u003e\nSTRBP integrates into pathways associated with RNA processing and regulation. It plays a role in the spermatogenesis pathway where it interacts with proteins like DDX4 also known as VASA a known component of the germ cell development process. STRBP's activity in these pathways is important for understanding RNA dynamics during the progression of spermatogenesis and the maintenance of germ cell integrity.\u003cbr\u003e\nSTRBP has been studied concerning its potential link to male infertility. Alterations or abnormal expression patterns of STRBP may disrupt normal spermatogenesis potentially leading to infertility issues. Additionally connections have been proposed between STRBP and another protein YBX3 known to impact RNA stability which may also contribute to reproductive dysfunctions when dysregulated. Further studies continue to elucidate STRBP's involvement in these health conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854227361961,"sku":"ab237682","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab237682","provider":"Iright","version":"1.0","type":"link"}