{"product_id":"abcam-ab237746","title":"Abcam, ab237746, Recombinant UVSX protein (Tagged)","description":"\u003cp\u003eSize: 20µg \/ 100µg\u003cbr\u003e\nRecombinant UVSX protein (Tagged) is a Enterobacteria phage T4 Full Length protein, in the 1 to 391 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P04529,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Enterobacteria phage T4,\u003cbr\u003e\nStorage buffer:pH: 7.2 - 7.4Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUVSX also known as Ubiquitin Variant X is a protein involved in protein ubiquitination. It has a molecular mass of approximately 37 kDa. UVSX is primarily expressed in the liver and kidney where it regulates various cellular processes. As a ubiquitin-like protein it binds to substrates tagging them for degradation via the proteasome pathway—a critical mechanism for maintaining protein homeostasis within cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUVSX functions as an important component in biochemical pathways involved in protein turnover and stress responses. It is not part of a larger protein complex but operates independently to facilitate the breakdown of misfolded or damaged proteins. By modulating the ubiquitin-proteasome system UVSX ensures that cells eliminate excess proteins which is important for cell health and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nUVSX integrates into the proteasome pathway specifically influencing protein degradation processes. It closely interacts with the E3 ubiquitin ligase another pivotal protein in this system to select specific substrates for degradation. Additionally UVSX has a role in the cell cycle regulation pathway impacting cellular proliferation and division.\u003cbr\u003e\nUVSX contributes to the pathogenesis of cancers and neurodegenerative diseases. For example its dysfunction or overexpression can lead to uncontrolled cell growth in certain types of cancer. The protein also links to Alzheimer's disease with aberrant UVSX activity affecting the accumulation of damaged proteins in neurons potentially worsening disease progression. UVSX's interaction with protein targets like p53—a tumor suppressor protein—illustrates its involvement in both these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843898790057,"sku":"ab237746","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab237746","provider":"Iright","version":"1.0","type":"link"}