{"product_id":"abcam-ab237751","title":"Abcam, ab237751, Anti-ATG4D antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal ATG4D antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ATG4D aa 1-50.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human ATG4D aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q86TL0\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nATG4D also known as Autophagin-4 is a protein that plays a mechanical role in the autophagy process. It is an integral cysteine protease with a molecular mass of around 50 kDa. This protein is expressed across various tissues prominently in skeletal and cardiac muscle as well as in the nervous system. Its mechanical function involves the cleavage of LC3 proteins and other ATG8 family members which are essential steps for autophagosome maturation and function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe action of ATG4D facilitates the cellular autophagy process. It is not part of a larger protein complex but functions independently to regulate the recycling of cytoplasmic components. By ensuring the proper processing of LC3 ATG4D supports the degradation of damaged organelles and proteins maintaining cellular homeostasis. The protein’s involvement in pathways promotes cellular survival during stress conditions such as nutrient deprivation.\u003cbr\u003e\nPathways\u003cbr\u003e\nATG4D primarily participates in the autophagy and mitophagy pathways. It is closely related to proteins such as ATG3 and ATG7 which coordinate to ensure the efficient conjugation and lipidation of ATG8 family members. In the mitophagy pathway it contributes to the selective degradation of mitochondria stabilizing mitochondrial quality control which is important for energy balance in cells.\u003cbr\u003e\nATG4D has connections to neurodegenerative diseases and cancer. Abnormal autophagy processes where ATG4D functions can contribute to conditions such as Parkinson's disease where defective mitophagy leads to neuronal cell death. In cancer the regulation of autophagy by ATG4D can influence tumor development and progression. Proteins such as p62\/SQSTM1 linked to autophagy and parkin linked to mitophagy further demonstrate the role of ATG4D in these diseases indicating its importance in pathological conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854170902697,"sku":"ab237751","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab237751","provider":"Iright","version":"1.0","type":"link"}